Innate Immune Response of Human Embryonic Stem Cell-Derived Fibroblasts and Mesenchymal Stem Cells to Periodontopathogens
المؤلفون المشاركون
Islam, Intekhab
Cao, Tong
Sriram, Gopu
Natu, Vaishali Prakash
Fu, Xin
Seneviratne, Chaminda Jayampath
Tan, Kai Soo
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-25
دولة النشر
مصر
عدد الصفحات
15
الملخص EN
Periodontitis involves complex interplay of bacteria and host immune response resulting in destruction of supporting tissues of the tooth.
Toll-like receptors (TLRs) play a role in recognizing microbial pathogens and eliciting an innate immune response.
Recently, the potential application of multipotent stem cells and pluripotent stem cells including human embryonic stem cells (hESCs) in periodontal regenerative therapy has been proposed.
However, little is known about the impact of periodontopathogens on hESC-derived progenies.
This study investigates the effects of heat-killed periodontopathogens, namely, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, on TLR and cytokine expression profile of hESC-derived progenies, namely, fibroblasts (hESC-Fib) and mesenchymal stem cells (hESC-MSCs).
Additionally, the serotype-dependent effect of A.
actinomycetemcomitans on hESC-derived progenies was explored.
Both hESC-Fib and hESC-MSCs constitutively expressed TLR-2 and TLR-4.
hESC-Fib upon exposure to periodontopathogens displayed upregulation of TLRs and release of cytokines (IL-1β, IL-6, and IL-8).
In contrast, hESC-MSCs were largely nonresponsive to bacterial challenge, especially in terms of cytokine production.
Further, exposure of hESC-Fib to A.
actinomycetemcomitans serotype c was associated with higher IL-8 production than serotype b.
In contrast, the hESC-MSCs displayed no serotype-dependent response.
Differential response of the two hESC progenies implies a phenotype-dependent response to periodontopathogens and supports the concept of immunomodulatory properties of MSCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sriram, Gopu& Natu, Vaishali Prakash& Islam, Intekhab& Fu, Xin& Seneviratne, Chaminda Jayampath& Tan, Kai Soo…[et al.]. 2016. Innate Immune Response of Human Embryonic Stem Cell-Derived Fibroblasts and Mesenchymal Stem Cells to Periodontopathogens. Stem Cells International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1117336
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sriram, Gopu…[et al.]. Innate Immune Response of Human Embryonic Stem Cell-Derived Fibroblasts and Mesenchymal Stem Cells to Periodontopathogens. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1117336
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sriram, Gopu& Natu, Vaishali Prakash& Islam, Intekhab& Fu, Xin& Seneviratne, Chaminda Jayampath& Tan, Kai Soo…[et al.]. Innate Immune Response of Human Embryonic Stem Cell-Derived Fibroblasts and Mesenchymal Stem Cells to Periodontopathogens. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1117336
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117336
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر