Cytotoxicity Evaluation of Ammonia-Modified Graphene Oxide Particles in Lung Cancer Cells and Embryonic Stem Cells
المؤلفون المشاركون
Keremidarska-Markova, Milena
Hristova-Panusheva, Kamelia
Andreeva, Tonya
Wang, Dayong
Krasteva, Natalia
Speranza, G.
المصدر
Advances in Condensed Matter Physics
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Potential toxicity of graphene oxide (GO) is a subject of increasing research interest in the recent years.
Here, we have evaluated the cytotoxicity of ammonia-modified GO (GO-NH2) and pristine GO particles in human lung cancer cells, A549 and embryonic stem cells, Lep3 exposed to different particles concentrations (0.1, 1, 10, 20, and 50 μg/ml) for different times (24 and 48h).
Compared with GO, GO-NH2 particles possessed smaller size, positive surface charge and higher thickness.
An increased propensity to aggregation in cell cultures was also found for GO-NH2 particles.
Cytotoxicity evaluation revealed that GO-NH2 particles are more toxic than pristine GO.
Applied at concentrations of 10, 20 and 50 μg/ml for 24h they affect significantly cell morphology of viable embryonic stem cells whereas human lung cancer A549 cells seem to be relatively more resistant to short-time exposure.
After 48h exposure however cell proliferation of A549 cells was strongly suppressed in a dose-dependent manner while the proliferation ability of embryonic stem cells was not affected.
These results suggested that both GO particles exert different degree of cytotoxicity which is time, dose and cell dependent.
In general, ammonia-modified GO particles are more toxic than the pristine GO which should be taken into account for future biomedical applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Keremidarska-Markova, Milena& Hristova-Panusheva, Kamelia& Andreeva, Tonya& Speranza, G.& Wang, Dayong& Krasteva, Natalia. 2018. Cytotoxicity Evaluation of Ammonia-Modified Graphene Oxide Particles in Lung Cancer Cells and Embryonic Stem Cells. Advances in Condensed Matter Physics،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1117369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Keremidarska-Markova, Milena…[et al.]. Cytotoxicity Evaluation of Ammonia-Modified Graphene Oxide Particles in Lung Cancer Cells and Embryonic Stem Cells. Advances in Condensed Matter Physics No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1117369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Keremidarska-Markova, Milena& Hristova-Panusheva, Kamelia& Andreeva, Tonya& Speranza, G.& Wang, Dayong& Krasteva, Natalia. Cytotoxicity Evaluation of Ammonia-Modified Graphene Oxide Particles in Lung Cancer Cells and Embryonic Stem Cells. Advances in Condensed Matter Physics. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1117369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر