Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment
المؤلفون المشاركون
Günter, Julia
Wolint, Petra
Bopp, Annina
Steiger, Julia
Cambria, Elena
Hoerstrup, Simon P.
Emmert, Maximilian Y.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-17
دولة النشر
مصر
عدد الصفحات
20
الملخص EN
More people die annually from cardiovascular diseases than from any other cause.
In particular, patients who suffer from myocardial infarction may be affected by ongoing adverse remodeling processes of the heart that may ultimately lead to heart failure.
The introduction of stem and progenitor cell-based applications has raised substantial hope for reversing these processes and inducing cardiac regeneration.
However, current stem cell therapies using single-cell suspensions have failed to demonstrate long-lasting efficacy due to the overall low retention rate after cell delivery to the myocardium.
To overcome this obstacle, the concept of 3D cell culture techniques has been proposed to enhance therapeutic efficacy and cell engraftment based on the simulation of an in vivo-like microenvironment.
Of great interest is the use of so-called microtissues or spheroids, which have evolved from their traditional role as in vitro models to their novel role as therapeutic agents.
This review will provide an overview of the therapeutic potential of microtissues by addressing primarily cardiovascular regeneration.
It will accentuate their advantages compared to other regenerative approaches and summarize the methods for generating clinically applicable microtissues.
In addition, this review will illustrate the unique properties of the microenvironment within microtissues that makes them a promising next-generation therapeutic approach.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Günter, Julia& Wolint, Petra& Bopp, Annina& Steiger, Julia& Cambria, Elena& Hoerstrup, Simon P.…[et al.]. 2016. Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment. Stem Cells International،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1117370
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Günter, Julia…[et al.]. Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1117370
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Günter, Julia& Wolint, Petra& Bopp, Annina& Steiger, Julia& Cambria, Elena& Hoerstrup, Simon P.…[et al.]. Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1117370
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117370
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر