Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews

المؤلفون المشاركون

Ruan, Guang-ping
Pang, Rong-qing
Yin, Cunping
Liang, Yuan
Zhang, Jian
Li, Zian
Pan, Xinghua

المصدر

Stem Cells International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-08-29

دولة النشر

مصر

عدد الصفحات

9

الملخص EN

Hindlimb ischemia is still a clinical problem with high morbidity and mortality.

Patients suffer from consequent rest pain, ulcers, cool limbs, and even amputation.

Angiogenesis is a promising target for the treatment of ischemic limbs, providing extra blood for the ischemic region.

In the present study, we investigated the role of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in regulating angiogenesis and relieving hindlimb ischemia.

UC-MSCs were isolated from the umbilical cord of tree shrews.

Angiography results showed that UC-MSCs injection significantly promoted angiogenesis in tree shrews.

Moreover, the ankle brachial index, transcutaneous oxygen pressure, blood perfusion, and capillary/muscle fiber ratio were all markedly increased by the application of UC-MSCs.

In addition, the conditioned culture of human umbilical vein endothelial cells using medium collected from UC-MSCs showed higher expression of angiogenic markers and improved migration ability.

In short, the isolated UC-MSCs notably contributed to restoring blood supply and alleviating the symptoms of limb ischemia through enhancing angiogenesis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yin, Cunping& Liang, Yuan& Zhang, Jian& Ruan, Guang-ping& Li, Zian& Pang, Rong-qing…[et al.]. 2016. Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117461

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yin, Cunping…[et al.]. Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1117461

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yin, Cunping& Liang, Yuan& Zhang, Jian& Ruan, Guang-ping& Li, Zian& Pang, Rong-qing…[et al.]. Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117461

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1117461