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Traditional Chinese Medicine Extract from Huaier Increases the Expression of Duffy Antigen Receptor for Chemokines and Reduces the Expression of Its Ligands
المؤلفون المشاركون
Chen, Qianjun
Chen, Ying
Xie, Fengfeng
Peng, Hui
Wu, Yanlan
Zhong, Shaowen
Wang, Zhiyu
Li, Wenxia
Xie, Wanjun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
The aim of the present study is to investigate whether the aqueous extract from Huaier, a traditional Chinese medicine (TCM), can affect the expression of Duffy antigen receptor for chemokines (DARC) and its ligands.
Moreover, we compare the status of DARC in primary and metastatic breast cancer tissues from the same patient.
Methods.
Immunohistochemistry was used to detect the expression of DARC in primary and metastatic focuses in 30 patients with breast cancer.
The effect of Huaier aqueous extract on the expression of DARC and its ligands was investigated by quantitative real-time polymerase chain reaction, Western blotting, and enzyme-linked immunosorbent assay.
Results.
The expression score of DARC in primary focuses was significantly higher than that in metastatic focuses, while changes of ER, PR, and HER2 receptors were not significantly different between primary and metastatic focuses.
Huaier aqueous extract promoted the expression of DARC and reduced the secretion of CC chemokine ligand 2 (CCL-2), CXC chemokine ligand 8 (CXCL-8, IL-8), matrix metalloproteinase 2 (MMP-2), and CXC chemokine ligand 1 (CXCL-1).
Conclusion.
The present study demonstrates that difference in expression level of DARC between primary and metastatic focuses of breast cancer was significant, while differences in expression of ER, PR, and HER2 between primary and metastatic focuses were not significant.
DARC may play a negative role in the metastasis of breast cancer.
Traditional Chinese medicine extract from Huaier can increase DARC expression and reduce the expression of its ligands such as CCL-2, IL-8, MMP-2, and CXCL-1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Ying& Chen, Qianjun& Xie, Fengfeng& Peng, Hui& Wu, Yanlan& Zhong, Shaowen…[et al.]. 2018. Traditional Chinese Medicine Extract from Huaier Increases the Expression of Duffy Antigen Receptor for Chemokines and Reduces the Expression of Its Ligands. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Ying…[et al.]. Traditional Chinese Medicine Extract from Huaier Increases the Expression of Duffy Antigen Receptor for Chemokines and Reduces the Expression of Its Ligands. Analytical Cellular Pathology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1117495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Ying& Chen, Qianjun& Xie, Fengfeng& Peng, Hui& Wu, Yanlan& Zhong, Shaowen…[et al.]. Traditional Chinese Medicine Extract from Huaier Increases the Expression of Duffy Antigen Receptor for Chemokines and Reduces the Expression of Its Ligands. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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