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Positive Association between TGFB1 Gene and Susceptibility to Idiopathic Scoliosis in Bulgarian Population
المؤلفون المشاركون
Savov, Alexey
Nikolova, Svetla
Dikova, Milka
Dikov, Dobrin
Djerov, Assen
Kremensky, Ivo
Loukanov, Alexandre
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Idiopathic scoliosis (IS) is a common medical condition beginning in childhood and characterized by strong evidence for a genetic susceptibility to three-dimensional spinal deformity.
The primary goal of the current case-control study is to examine the association between the TGFB1 (-509C/T) functional polymorphic variant and genetic predisposition to IS in the Bulgarian population and the genotype-phenotype correlations in distinct case-control subgroups based on age at onset, family history, and gender.
A total of 127 patients with primary scoliosis and 254 gender-matched control subjects were recruited.
The mean Cobb angle was 53.8 ± 21.2°.
Genotyping of cases and controls was performed using the TaqMan real-time amplification technique.
The results were processed statistically using Pearson’s Chi-squared test and Fisher’s exact test with a value of p less than 0.05 as statistically significant.
The polymorphic T allele and TT genotype were associated with a greater incidence of IS and can be considered as predisposing factors with a moderate effect on deformity development.
The current results suggested that there was a genetic predisposition in early and late onset IS and familial, sporadic, and female cases.
Nevertheless, replication studies are needed to reveal the relationship between the TGFB1 locus and certain subtypes of IS in different populations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nikolova, Svetla& Dikova, Milka& Dikov, Dobrin& Djerov, Assen& Savov, Alexey& Kremensky, Ivo…[et al.]. 2018. Positive Association between TGFB1 Gene and Susceptibility to Idiopathic Scoliosis in Bulgarian Population. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1117497
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nikolova, Svetla…[et al.]. Positive Association between TGFB1 Gene and Susceptibility to Idiopathic Scoliosis in Bulgarian Population. Analytical Cellular Pathology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1117497
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nikolova, Svetla& Dikova, Milka& Dikov, Dobrin& Djerov, Assen& Savov, Alexey& Kremensky, Ivo…[et al.]. Positive Association between TGFB1 Gene and Susceptibility to Idiopathic Scoliosis in Bulgarian Population. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1117497
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117497
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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