High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma
المؤلفون المشاركون
Wu, Bo
Yang, Haihua
Ying, Shenpeng
Lu, Hongsheng
Wang, Wei
Lv, Jiaming
Xiong, Huacai
Hu, Wei
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Aims.
In patients with nasopharyngeal carcinoma (NPC), local treatment failure and distant metastasis contribute largely to poor outcomes.
The nasopharynx is an important lymphoid tissue, and NPC tumourigenesis and development are partly attributed to immune system disorders.
Human leukocyte antigen F (HLA-F) has shown a close correlation with NPC in many genome-wide association studies (GWASs).
However, clinical studies rarely explore the relationship of HLA-F expression with the clinical parameters and outcomes in patients with NPC.
Methods.
In this study, we used immunohistochemistry to evaluate HLA-F expression in 74 paraffin-embedded NPC tissue sections and then analysed the association between HLA-F expression and clinical parameters and outcomes.
The plasma concentration of soluble HLA-F (sHLA-F) in NPC patients and normal controls was also detected, via enzyme-linked immunosorbent assay (ELISA).
Results.
Low, moderate, and high HLA-F expression levels were observed in 47.3% (35/74), 35.1% (26/74), and 17.6% (13/74), respectively, of the tissue samples.
HLA-F expression showed a significant correlation with local recurrence (p=0.037) and distant metastasis (p=0.024) and was also an independent factor for local recurrence-free survival (LRFS; p=0.016) and distant metastasis-free survival (DMFS; p=0.004).
Although the mean concentration of plasma sHLA-F in the NPC patients was higher than that in the normal controls (13.63 pg/ml vs.
10.06 pg/ml), no statistical significance was observed (p=0.118).
Conclusions.
Our study provides the first evidence that high HLA-F expression is associated with NPC local recurrence and distant metastasis and may be regarded as a poor prognostic factor for NPC patients.
Additional studies using larger sample sizes may be necessary to determine whether sHLA-F is a feasible NPC diagnostic indicator.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Bo& Yang, Haihua& Ying, Shenpeng& Lu, Hongsheng& Wang, Wei& Lv, Jiaming…[et al.]. 2018. High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117500
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Bo…[et al.]. High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma. Analytical Cellular Pathology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1117500
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Bo& Yang, Haihua& Ying, Shenpeng& Lu, Hongsheng& Wang, Wei& Lv, Jiaming…[et al.]. High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117500
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117500
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر