Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity
المؤلفون المشاركون
Ishida, Masahiko
Sugisawa, Haruki
Kishikawa, Akiko
Shima, Kazuhiro
Ogawa, Saika
Qi, Jiawei
Shen, Wei-Ren
Kitaura, Hideki
Kimura, Keisuke
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Lipopolysaccharide (LPS) is an endotoxin and bacterial cell wall component that is capable of inducing inflammation and immunological activity.
Muramyl dipeptide (MDP), the minimal essential structural unit responsible for the immunological activity of peptidoglycans, is another inflammation-inducing molecule that is ubiquitously expressed by bacteria.
Several studies have shown that inflammation-related biological activities were synergistically induced by interactions between LPS and MDP.
MDP synergistically enhances production of proinflammatory cytokines that are induced by LPS exposure.
Injection of MDP induces lethal shock in mice challenged with LPS.
LPS also induces osteoclast formation and pathological bone resorption; MDP enhances LPS induction of both processes.
Furthermore, MDP enhances the LPS-induced receptor activator of NF-κB ligand (RANKL) expression and toll-like receptor 4 (TLR4) expression both in vivo and in vitro.
Additionally, MDP enhances LPS-induced mitogen-activated protein kinase (MAPK) signaling in stromal cells.
Taken together, these findings suggest that MDP plays an important role in LPS-induced biological activities.
This review discusses the role of MDP in LPS-mediated biological activities, primarily in relation to osteoclastogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kitaura, Hideki& Ishida, Masahiko& Kimura, Keisuke& Sugisawa, Haruki& Kishikawa, Akiko& Shima, Kazuhiro…[et al.]. 2018. Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kitaura, Hideki…[et al.]. Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity. Analytical Cellular Pathology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1117506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kitaura, Hideki& Ishida, Masahiko& Kimura, Keisuke& Sugisawa, Haruki& Kishikawa, Akiko& Shima, Kazuhiro…[et al.]. Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر