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Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland
المؤلفون المشاركون
Kim, Sun Eui
Baek, Hye Jung
Park, Eun Jung
Lim, Sung Chul
Kim, Sang Soo
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Environmental and genetic factors exert important influences on lifespan and neoplastic transformation.
We have previously shown that spontaneous tumors form frequently in mice homozygous for a full-length Brca1 deletion.
In general, mutations of BRCA1 are closely associated with induction of breast and ovarian cancers but are also known to contribute to the incidence of other cancers at a low frequency.
Female Brca1-mutant mice (Brca1co/coMMTV-cre) were generated by crossing Brca1 conditional knockout mice and MMTV-cre mice, and the occurrence of lacrimal gland abnormalities and tumors was followed until mice reached 18 months of age.
Lacrimal gland tumors, which occur at a very low frequency in the human population (1 per 1,000,000 per year), were detected in 7 cases of Brca1co/coMMTV-cre mice (2.75%) older than 9 months of age.
None of seven mice exhibited any abnormality in the mammary gland including neoplasia, suggesting lacrimal gland tumor is spontaneously and independently formed.
These tumors, which were detected in seven mutant mice that displayed exophthalmoses, were malignant, originated from epithelial cells, and were identified as acinic cell carcinoma by pathological analysis.
Further analysis revealed that tumorigenesis was accompanied by the accumulation of cyclin D1 and decreased expression of the cellular oncogenes, c-Myc, c-Jun, and c-Raf.
Tumors also exhibited rearrangement of cytoskeletal proteins, including β-catenin, keratin 5, and vimentin, depending on tumor progression.
These results suggest that BRCA1 is involved in genetic stability of the lacrimal gland, providing new insight into genomic instability in organism maintenance and tumorigenesis of the lacrimal gland.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Sun Eui& Baek, Hye Jung& Park, Eun Jung& Lim, Sung Chul& Kim, Sang Soo. 2018. Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117513
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Sun Eui…[et al.]. Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland. Analytical Cellular Pathology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1117513
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Sun Eui& Baek, Hye Jung& Park, Eun Jung& Lim, Sung Chul& Kim, Sang Soo. Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117513
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117513
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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