Construction of Gene Regulatory Networks Using Recurrent Neural Networks and Swarm Intelligence
المؤلفون المشاركون
Khan, Abhinandan
Mandal, Sudip
Pal, Rajat Kumar
Saha, Goutam
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
We have proposed a methodology for the reverse engineering of biologically plausible gene regulatory networks from temporal genetic expression data.
We have used established information and the fundamental mathematical theory for this purpose.
We have employed the Recurrent Neural Network formalism to extract the underlying dynamics present in the time series expression data accurately.
We have introduced a new hybrid swarm intelligence framework for the accurate training of the model parameters.
The proposed methodology has been first applied to a small artificial network, and the results obtained suggest that it can produce the best results available in the contemporary literature, to the best of our knowledge.
Subsequently, we have implemented our proposed framework on experimental (in vivo) datasets.
Finally, we have investigated two medium sized genetic networks (in silico) extracted from GeneNetWeaver, to understand how the proposed algorithm scales up with network size.
Additionally, we have implemented our proposed algorithm with half the number of time points.
The results indicate that a reduction of 50% in the number of time points does not have an effect on the accuracy of the proposed methodology significantly, with a maximum of just over 15% deterioration in the worst case.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Abhinandan& Mandal, Sudip& Pal, Rajat Kumar& Saha, Goutam. 2016. Construction of Gene Regulatory Networks Using Recurrent Neural Networks and Swarm Intelligence. Scientifica،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1117518
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Abhinandan…[et al.]. Construction of Gene Regulatory Networks Using Recurrent Neural Networks and Swarm Intelligence. Scientifica No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1117518
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Abhinandan& Mandal, Sudip& Pal, Rajat Kumar& Saha, Goutam. Construction of Gene Regulatory Networks Using Recurrent Neural Networks and Swarm Intelligence. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1117518
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117518
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر