Synthesis and Antibacterial Activity of 3-(Substituted)‎-2-(4-oxo-2-phenylquinazolin-3(4H)‎-ylamino)‎quinazolin-4(3H)‎-one

المؤلفون المشاركون

Appani, Ramgopal
Bhukya, Baburao
Kiran, G.

المصدر

Scientifica

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-04-07

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض

الملخص EN

A series of novel 3-(substituted)-2-(substituted quinazolinylamino)quinazolin-4(3H)-ones were synthesized by the reaction of 3-(substituted)-2-hydrazino-quinazoline-4(3H)-ones with 2-phenyl-3,1-benzoxazin-4-one.

The starting materials 3-(substituted)-2-hydrazino-quinazolin-4(3H)-ones were synthesized from various primary amines by a multistep synthesis.

All the title compounds were tested for their antibacterial activity using ciprofloxacin as reference standard.

Compounds 3-(4-fluorophenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one (9a) and 3-(4-chlorophenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one (9h) emerged as the most active compounds of the series.

These compounds have shown most potent antibacterial activity against the tested organisms of Proteus vulgaris and Bacillus subtilis having zone of inhibition values of 1.1 cm and 1.4 cm for compound 9a 1.2 cm and 1.0 cm for compound 9h, respectively.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Appani, Ramgopal& Bhukya, Baburao& Kiran, G.. 2016. Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one. Scientifica،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1117524

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Appani, Ramgopal…[et al.]. Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one. Scientifica No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1117524

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Appani, Ramgopal& Bhukya, Baburao& Kiran, G.. Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1117524

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1117524