Identification of Levels of Serum Amyloid A and Apolipoprotein A1 in Serum Proteomic Analysis of Neuropsychiatric Systemic Lupus Erythematosus Patients
المؤلفون المشاركون
Vasquez, Gloria
Rojas, Mauricio
Restrepo, Mauricio
Duarte-Delgado, Nancy P.
Lujan, Tania P.
Arbeláez-Cortés, Álvaro
García-Valencia, Jenny
Zapata, Adriana
Ortiz-Reyes, Blanca L.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) has multiple pathogenic mechanisms that cause diverse manifestations and whose diagnosis is challenging because of the absence of appropriate diagnostic tests.
In the present study the application of proteomics using two-dimensional electrophoresis (2D) and mass spectrometry (MS) allowed the comparison of the protein profile of the serum low and high abundance protein fractions of NPSLE patients (NPSLE group) and SLE without neuropsychiatric syndromes (SLE group), Neuropsychiatric syndromes not associated with SLE (NPnoSLE groups), and healthy controls (CTRL group).
The gels obtained were digitalized and analyzed with the PDQuest software.
The statistical analysis of the spots was performed using the nonparametric Kruskal Wallis and Dunn's multiple comparison tests.
Two spots showed significant differences and were identified by MS.
Spot 4009 was significantly lower in NPSLE with regard to NPnoSLE (p= 0,004) and was identified as apolipoprotein A1 (APOA1) (score 809-1132).
Spot 8001 was significantly higher in NPSLE regarding CTRL and NPnoSLE (p= 0,01 y 0,03, respectively) and was identified as serum amyloid A (SAA) (score 725-2488).
The proinflammatory high density lipoproteins (HDL) have been described in SLE.
In this HDL the decrease of APOA1 is followed by an increase in SAA.
This altered level of both proteins may be related to the inflammatory state that is characteristic of an autoimmune disease like SLE, but this is not specific for NPSLE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Duarte-Delgado, Nancy P.& Lujan, Tania P.& Arbeláez-Cortés, Álvaro& García-Valencia, Jenny& Zapata, Adriana& Rojas, Mauricio…[et al.]. 2018. Identification of Levels of Serum Amyloid A and Apolipoprotein A1 in Serum Proteomic Analysis of Neuropsychiatric Systemic Lupus Erythematosus Patients. Autoimmune Diseases،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117617
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Duarte-Delgado, Nancy P.…[et al.]. Identification of Levels of Serum Amyloid A and Apolipoprotein A1 in Serum Proteomic Analysis of Neuropsychiatric Systemic Lupus Erythematosus Patients. Autoimmune Diseases No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1117617
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Duarte-Delgado, Nancy P.& Lujan, Tania P.& Arbeláez-Cortés, Álvaro& García-Valencia, Jenny& Zapata, Adriana& Rojas, Mauricio…[et al.]. Identification of Levels of Serum Amyloid A and Apolipoprotein A1 in Serum Proteomic Analysis of Neuropsychiatric Systemic Lupus Erythematosus Patients. Autoimmune Diseases. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117617
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117617
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر