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Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus
المؤلفون المشاركون
Panigrahi, Ghanshyam
Panda, Chhayakanta
Patra, Arjun
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Sesbania grandiflora has been traditionally used as antidiabetic, antioxidant, antipyretic, and expectorant and in the management of various ailments.
Materials and Methods.
The study evaluates the antidiabetic activity of methanolic extract of Sesbania grandiflora (MESG) in type 2 diabetic rats induced by low dose streptozotocine and high fat diet.
Diabetic rats were given vehicle, MESG (200 and 400 mg/kg, p.o.), and the standard drug, metformin (10 mg/kg), for 28 days.
During the experimental period, body weight, abdominal girth, food intake, fasting serum glucose, urine analyses were measured.
Insulin tolerance test was carried out on 25th day of drug treatment period.
Serum analyses for lipid profile and SGOT and SGPT and serums creatinine, urea, protein, SOD, and MDA were also carried out.
At the end of the experiment, animals were euthanized, the liver and pancreas were immediately dissected out, and the ratio of pancreas to body weight and hepatic glycogen were calculated.
Results.
MESG (200 and 400 mg/kg, p.o.) induced significant reduction (P<0.05) of raised blood glucose levels in diabetic rats and also restored other parameters to normal level.
Conclusion.
Therefore, it is concluded that MESG has potential antihyperglycemic and antihyperlipemic activities and alleviate insulin resistance conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Panigrahi, Ghanshyam& Panda, Chhayakanta& Patra, Arjun. 2016. Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus. Scientifica،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117676
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Panigrahi, Ghanshyam…[et al.]. Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus. Scientifica No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1117676
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Panigrahi, Ghanshyam& Panda, Chhayakanta& Patra, Arjun. Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117676
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117676
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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