Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine
المؤلفون المشاركون
Samarah, Fekri
Srour, Mahmoud A.
Yaseen, Dirgham
Dumaidi, Kamal
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Transfusion of red blood cells (RBC) is an essential therapeutic tool in sickle cell disease (SCD).
Repeated RBC transfusions can cause alloimmunization which causes difficulty in cross-matching and finding compatible blood for transfusions.
This study aimed to investigate the frequency of RBC alloimmunization and related risk factors among Palestinian SCD patients.
Materials and Methods.
A multicenter cross-sectional study on 116 previously transfused SCD patients from three centers in West Bank, Palestine.
Demographic, medical data and history of transfusion were recorded.
Blood samples were collected from transfused consenting SCD patients.
Gel card method was used for antibody screening and identification.
In all patients, autocontrol and direct antiglobulin (DAT) test were performed using polyspecific (anti-IgG + C3d) anti-human globulin (AHG) gel cards for the detection of autoantibodies.
Results.
Of the SCD patients, 62 (53.4%) patients were HbSS and 54 (46.6%) patients were sickle β-thalassemia (S/β-thal).
There were 53 (45.7%) females and 63 (54.3%) males.
Mean age was 18.8 years (range 3-53 years).
The frequency of RBC alloimmunization among SCD patients was 7.76%, with anti-K showing the highest frequency (33.3%) followed by anti-E (22.2%), anti-D (11.1%), anti-C (11.1%), and anti-c (11.1%).
All reported IgG alloantibodies were directed against antigens in the Rh (66.7%) and Kell (33.3%) systems.
Older ages of patients, increased number of blood units transfused, and splenectomy were the commonest risk factors for alloimmunization in our study.
Conclusions.
RBC alloimmunization rate among Palestinian SCD patients is low compared to neighboring countries and countries all over the world but still warrants more attention.
Phenotyping of donors/recipients’ RBC for Rh antigens and K1 (partial phenotype matching) before their first transfusion may reduce the incidence of alloimmunization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Samarah, Fekri& Srour, Mahmoud A.& Yaseen, Dirgham& Dumaidi, Kamal. 2018. Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine. Advances in Hematology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117748
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Samarah, Fekri…[et al.]. Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine. Advances in Hematology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1117748
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Samarah, Fekri& Srour, Mahmoud A.& Yaseen, Dirgham& Dumaidi, Kamal. Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine. Advances in Hematology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117748
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117748
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر