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Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line
المؤلفون المشاركون
Abulnaja, Khalid O.
Hasan, Mohammed Nihal
Razvi, Syed Shoeb
Choudhry, Hani
Hassan, Mohammed A.
Moselhy, Said Salama
Kumosani, Taha Abduallah
Zamzami, Mazin A.
Halwani, Majed A.
Ragoussis, Jiannis
Wu, Wei
Bronner, Christian
Asami, Tadao
Alhosin, Mahmoud
al-Malki, Abdulrahman L.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Human hepatocellular carcinoma (HCC) is the most common and recurrent type of primary adult liver cancer without any effective therapy.
Plant-derived compounds acting as anticancer agents can induce apoptosis by targeting several signaling pathways.
Strigolactone (SL) is a novel class of phytohormone, whose analogues have been reported to possess anticancer properties on a panel of human cancer cell lines through inducing cell cycle arrest, destabilizing microtubular integrity, reducing damaged in the DNA repair machinery, and inducing apoptosis.
In our previous study, we reported that a novel SL analogue, TIT3, reduces HepG2 cell proliferation, inhibits cell migration, and induces apoptosis.
To decipher the mechanisms of TIT3-induced anticancer activity in HepG2, we performed RNA sequencing and the differential expression of genes was analyzed using different tools.
RNA-Seq data showed that the genes responsible for microtubule organization such as TUBB, BUB1B, TUBG2, TUBGCP6, TPX2, and MAP7 were significantly downregulated.
Several epigenetic modulators such as UHRF1, HDAC7, and DNMT1 were also considerably downregulated, and this effect was associated with significant upregulation of various proapoptotic genes including CASP3, TNF-α, CASP7, and CDKN1A (p21).
Likewise, damaged DNA repair genes such as RAD51, RAD52, and DDB2 were also significantly downregulated.
This study indicates that TIT3-induced antiproliferative and proapoptotic activities on HCC cells could involve several signaling pathways.
Our results suggest that TIT3 might be a promising drug to treat HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hassan, Mohammed A.& Moselhy, Said Salama& Kumosani, Taha Abduallah& Zamzami, Mazin A.& Abulnaja, Khalid O.& Halwani, Majed A.…[et al.]. 2019. Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1117779
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hassan, Mohammed A.…[et al.]. Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line. Analytical Cellular Pathology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1117779
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hassan, Mohammed A.& Moselhy, Said Salama& Kumosani, Taha Abduallah& Zamzami, Mazin A.& Abulnaja, Khalid O.& Halwani, Majed A.…[et al.]. Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1117779
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117779
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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