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Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology
المؤلفون المشاركون
Căruntu, Constantin
Bostan, Marinela
Ignat, Simona Rebeca
Constantin, Carolina
Dinescu, Sorina
Marieta, Costache
Neagu, Monica
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-29
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The epithelial-mesenchymal transition (EMT) is a complex transformation process that induces local and distant progression of many malignant tumours.
Due to its complex array of proteins that are dynamically over-/underexpressed during this process, proteomic technologies gained their place in the EMT research in the last years.
Proteomics has identified new molecular pathways of this process and brought important insights to develop new therapy targets.
Various proteomic tools and multiple combinations were developed in this area.
Out of the proteomic technology armentarium, mass spectrometry and array technologies are the most used approaches.
The main characteristics of the proteomic technology used in this domain are high throughput and detection of minute concentration in small samples.
We present herein, using various proteomic technologies, the identification in cancer cell lines and in tumour tissue EMT-related proteins, proteins that are involved in the activation of different cellular pathways.
Proteomics has brought besides standard EMT markers (e.g., cell-cell adhesion proteins and transcription factors) other future potential markers for improving diagnosis, monitoring evolution, and developing new therapy targets.
Future will increase the proteomic role in clinical investigation and validation of EMT-related biomarkers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Neagu, Monica& Constantin, Carolina& Bostan, Marinela& Căruntu, Constantin& Ignat, Simona Rebeca& Dinescu, Sorina…[et al.]. 2019. Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1117815
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Neagu, Monica…[et al.]. Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology. Analytical Cellular Pathology No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1117815
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Neagu, Monica& Constantin, Carolina& Bostan, Marinela& Căruntu, Constantin& Ignat, Simona Rebeca& Dinescu, Sorina…[et al.]. Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1117815
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117815
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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