Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease
المؤلفون المشاركون
Zuo, Huanhuan
Xie, Xiaochen
Peng, Jiahuan
Wang, Lixin
Zhu, Rong
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII).
This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019.
Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD.
According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups.
The study group consisted of 101 patients complicated with PH, and the control group had 84 patients.
The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (p<0.05).
The blood biomarker levels were positively correlated with NT-proBNP levels, while they had no significant correlation with the estimated pulmonary arterial systolic pressure (PASP) other than PLR.
NLR, PLR, and SII values were all associated with PH (p<0.05) in the univariate analysis, but not in the multivariate analysis.
The AUC of NLR used for predicting PH was 0.701 and was higher than PLR and SII.
Using 4.659 as the cut-off value of NLR, the sensitivity was 81.2%, and the specificity was 59.5%.
In conclusion, these simple markers may be useful in the prediction of PH in patients with AECOPD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zuo, Huanhuan& Xie, Xiaochen& Peng, Jiahuan& Wang, Lixin& Zhu, Rong. 2019. Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zuo, Huanhuan…[et al.]. Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Analytical Cellular Pathology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1117853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zuo, Huanhuan& Xie, Xiaochen& Peng, Jiahuan& Wang, Lixin& Zhu, Rong. Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر