Modulation of Drug Resistance in Staphylococcus aureus with Coumarin Derivatives
المؤلفون المشاركون
Mendonça Junior, F. J. B.
Barbosa Filho, José Maria
Araújo, Rodrigo Santos Aquino de
Scotti, Luciana
Scotti, Marcus Tullius
Cruz, Ryldene Marques Duarte da
Falcão-Silva, Vivyanne dos Santos
Siqueira-Júnior, José Pinto de
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Semisynthetic and commercial coumarins were investigated for their antibacterial and adjuvant properties with antibiotic agents against norfloxacin, erythromycin, and tetracycline resistant Staphylococcus aureus as based on efflux mechanisms.
The coumarins and certain commercial antibiotics had their Minimum Inhibitory Concentrations determined by broth microdilution assay against resistant S.
aureus strains which overexpress efflux pump proteins.
For evaluation of the modulatory activity, the antibiotics MICs were determined in the presence of the coumarin derivatives at subinhibitory concentration.
Although the coumarins did not display relevant antibacterial activity (MIC ≥ 128 µg/mL), they did modulate the antibiotics activities.
Various coumarins, especially the alkylated derivatives in combination with antibiotics at subinhibitory concentrations, modulated antibiotic activity, reducing the MIC for tetracycline and norfloxacin by 2 to 8 times.
Polar Surface Area (PSA) studies were performed and the fact that the presence of apolar groups is an important factor for the modulatory activity of coumarins was corroborated.
Docking on the Penicillin-Binding Protein from MRSA identified that 18 is a potential ligand presenting low E b i n d i n g .
The results indicate that coumarin derivatives modulated antibiotic resistance and may be used as potential antibiotic adjuvants, acting by bacterial efflux pump inhibition in S.
aureus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Araújo, Rodrigo Santos Aquino de& Barbosa Filho, José Maria& Scotti, Marcus Tullius& Scotti, Luciana& Cruz, Ryldene Marques Duarte da& Falcão-Silva, Vivyanne dos Santos…[et al.]. 2016. Modulation of Drug Resistance in Staphylococcus aureus with Coumarin Derivatives. Scientifica،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1117857
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Araújo, Rodrigo Santos Aquino de…[et al.]. Modulation of Drug Resistance in Staphylococcus aureus with Coumarin Derivatives. Scientifica No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1117857
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Araújo, Rodrigo Santos Aquino de& Barbosa Filho, José Maria& Scotti, Marcus Tullius& Scotti, Luciana& Cruz, Ryldene Marques Duarte da& Falcão-Silva, Vivyanne dos Santos…[et al.]. Modulation of Drug Resistance in Staphylococcus aureus with Coumarin Derivatives. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1117857
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117857
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر