PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway
المؤلفون المشاركون
Kong, Xiangyu
Ai, Ganghao
Wang, Dai
Chen, Renzhen
Guo, Dongbei
Yao, Youliang
Wang, Kai
Liang, Guiye
Qi, Fengjie
Liu, Wenzhi
Zhang, Yongxing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
To assess the expression levels of exchange protein 1 directly activated by cAMP (Epac1) and phosphodiesterase 4 (PDE4) in rectal carcinoma, and their associations with clinicopathological indexes.
In addition, the associations of PDE4 and Epac1 with A-kinase anchor protein 95, connexin 43, cyclin D1, and cyclin E1 were evaluated.
Methods.
The PV-9000 two-step immunohistochemistry method was used to determine protein expression in 44 rectal carcinoma tissue samples and 16 paracarcinoma tissue specimens.
Results.
The positive rate of PDE4 protein expression in rectal carcinoma tissues was higher than that of paracarcinoma tissues (59.09% vs.
12.5%, P<0.05).
Similar findings were obtained for Epac1 (55% vs.
6.25%, P<0.05).
No significant associations of PDE4 and Epac1 with degree of differentiation, histological type, and lymph node metastasis were found in rectal carcinoma (P>0.05).
Correlations between PDE4 and Epac1, PDE4 and Cx43, PDE4 and cyclin E1, and Epac1 and Cx43 were observed (all P<0.05).
There was no correlation between the other protein pairs examined (P>0.05).
Conclusion.
PDE4 and Epac1 expression levels are increased in rectal carcinoma tissues, suggesting that the two proteins may be involved in the development of this malignancy.
Meanwhile, correlations between PDE4 and Epac1, PDE4 and Cx43, PDE4 and cyclin E1, and Epac1 and Cx43 suggested synergistic effects of these proteins in promoting rectal carcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kong, Xiangyu& Ai, Ganghao& Wang, Dai& Chen, Renzhen& Guo, Dongbei& Yao, Youliang…[et al.]. 2019. PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1117872
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kong, Xiangyu…[et al.]. PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway. Analytical Cellular Pathology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1117872
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kong, Xiangyu& Ai, Ganghao& Wang, Dai& Chen, Renzhen& Guo, Dongbei& Yao, Youliang…[et al.]. PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1117872
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117872
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر