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Diagnostic Value Investigation and Bioinformatics Analysis of miR-31 in Patients with Lymph Node Metastasis of Colorectal Cancer
المؤلفون المشاركون
Weng, Hong
Chen, Hao
Wang, Fu-Bing
Zhang, Wu-wen
Ming, Xin-liang
Rong, Yuan
Huang, Chao-qun
Bian, Jun-mei
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Colorectal cancer (CRC) is one of the most frequent cancers occurring in developed countries.
Distant CRC metastasis causes more than 90% of CRC-associated mortality.
MicroRNAs (miRNAs) play a key role in regulating tumor metastasis and could be potential diagnostic biomarkers in CRC patients.
This study is aimed at identifying miRNAs that can be used as diagnostic biomarkers for CRC metastasis.
Towards this goal, we compared the expression of five miRNAs commonly associated with metastasis (i.e., miR-10b, miR-200c, miR-155, miR-21, and miR-31) between primary CRC (pCRC) tissues and corresponding metastatic lymph nodes (mCRC).
Further, bioinformatics analysis of miR-31 was performed to predict target genes and related signaling pathways.
Results showed that miR-31, miR-21, miR-10b, and miR-155 expression was increased to different extents, while miR-200c expression was lower in mCRC than that in pCRC.
Moreover, we found that the level of both miR-31 and miR-21 was notably increased in pCRC when lymph node metastasis (LNM) was present, and the increase of miR-31 expression was more profound.
Hence, upregulated miR-31 and miR-21 expression might be a miRNA signature in CRC metastasis.
Moreover, we detected a higher miR-31 level in the plasma of CRC patients with LNM compared to patients without LNM or healthy individuals.
With the bioinformatics analysis of miR-31, 121 putative target genes and transition of mitotic cell cycle and Wnt signaling pathway were identified to possibly play a role in CRC progression.
We next identified seven hub genes via module analysis; of these, TNS1 was most likely to be the target of miR-31 and had significant prognostic value for CRC patients.
In conclusion, miR-31 is significantly increased in the cancer tissues and plasma of CRC patients with LNM; thus, a high level of miR-31 in the plasma is a potential biomarker for the diagnosis of LNM of CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Wu-wen& Ming, Xin-liang& Rong, Yuan& Huang, Chao-qun& Weng, Hong& Chen, Hao…[et al.]. 2019. Diagnostic Value Investigation and Bioinformatics Analysis of miR-31 in Patients with Lymph Node Metastasis of Colorectal Cancer. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1117915
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Wu-wen…[et al.]. Diagnostic Value Investigation and Bioinformatics Analysis of miR-31 in Patients with Lymph Node Metastasis of Colorectal Cancer. Analytical Cellular Pathology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1117915
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Wu-wen& Ming, Xin-liang& Rong, Yuan& Huang, Chao-qun& Weng, Hong& Chen, Hao…[et al.]. Diagnostic Value Investigation and Bioinformatics Analysis of miR-31 in Patients with Lymph Node Metastasis of Colorectal Cancer. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1117915
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117915
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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