Safety and Efficacy of Acute Clopidogrel Load in Patients with Moderate and Severe Ischemic Strokes
المؤلفون المشاركون
Martin-Schild, Sheryl
Tiu, Jonathan
Monlezun, Dominique J.
Rincon, Natalia
Valmoria, Melisa
Shaban, Amir
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-13
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
To study the safety and efficacy of a clopidogrel loading dose in patients with moderate and severe acute ischemic strokes.
Background.
The safety of clopidogrel loading has been extensively investigated in patients with minor strokes and transient ischemic attacks.
Methods.
Acute ischemic stroke patients presenting consecutively to our center from 07/01/08 to 07/31/13 were screened.
Clopidogrel loading was defined as at least 300 mg dose (with or without aspirin) given within 6 hours of admission.
We compared outcomes in patients with baseline NIHSS > 3 with and without clopidogrel loading.
Results.
Inclusion criteria were met for 1011 patients (43.6% females, 69.1% black, median age 63).
Patients with clopidogrel loading had lower baseline NIHSS than patients who were not loaded (8 versus 9, p = 0.005 ).
The two groups had similar risk for hemorrhagic transformation ( p = 0.918 ) and symptomatic hemorrhage ( p = 0.599 ).
Patients who were loaded had a lower rate of neurological worsening (38.9% versus 48.3%, p = 0.031 ) and less in-hospital mortality (4.3% versus 13.4%, p = 0.001 ) compared to those who were not loaded.
The likelihood of having a poor functional outcome did not differ between the two groups after adjusting for NIHSS on admission (OR = 0.71, 95% CI 0.4633–1.0906, p = 0.118 ).
Conclusion.
Clopidogrel loading dose was not associated with increased risk for hemorrhagic transformation or symptomatic intracranial hemorrhage in our retrospective study and was associated with reduced rates of neuroworsening following moderate and severe stroke.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shaban, Amir& Monlezun, Dominique J.& Rincon, Natalia& Tiu, Jonathan& Valmoria, Melisa& Martin-Schild, Sheryl. 2016. Safety and Efficacy of Acute Clopidogrel Load in Patients with Moderate and Severe Ischemic Strokes. Stroke Research and Treatment،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1118498
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shaban, Amir…[et al.]. Safety and Efficacy of Acute Clopidogrel Load in Patients with Moderate and Severe Ischemic Strokes. Stroke Research and Treatment No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1118498
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shaban, Amir& Monlezun, Dominique J.& Rincon, Natalia& Tiu, Jonathan& Valmoria, Melisa& Martin-Schild, Sheryl. Safety and Efficacy of Acute Clopidogrel Load in Patients with Moderate and Severe Ischemic Strokes. Stroke Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1118498
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1118498
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر