A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia
المؤلفون المشاركون
Ali, Eman Tariq
Jabbar, Azza Sajed
Mohammed, Ali Nazar
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Interleukin-6 (IL-6) proinflammatory cytokine is associated with the pathogenesis of rheumatoid arthritis and development of anemia in it.
This is a comparative study of inflammatory and hematological parameters in RA patients with anemia of chronic disease (ACD) and iron deficiency anemia (IDA).
It aimed to demonstrate the changes in serum level of IL-6, ferritin level, and hematological parameters in different groups of patients with RA and to find out the potential correlation between serum level of IL-6 and ferritin level and the relationship between serum level of IL-6 and iron status.
Methods.
The study included 89 patients from both sexes divided into four groups (group 1: 30 iron deficiency anemia (IDA), 59 RA; group 2: 20 RA-COMBI; group 3: 23 RA-ACD; and group 4: 16 nonanemic RA).
These different groups were compared with a healthy group of 50 healthy individuals.
Different blood parameters (WBC, RBC, HGB, HCT, MCV, and MCH) have been evaluated.
Serum concentrations of IL-6, hsCRP, anti-CCP, and ferritin were measured in all patients and healthy individual using enzyme-linked immunosorbent assay ELISA.
Results.
There were significant changes in most of blood parameters between the groups, and there was a significant increase in the levels of IL-6 among RA patients.
This increase was highly significant among RA-ACD patients in particular, and this elevation has been directly correlated with clinical indices of disease activity such as hsCRP, ESR, anti-CCP, and ferritin.
There was an inverse relationship between ferritin and all iron status parameter, such as RBC, HGB, and haematocrit.
Conclusion.
IL-6 and ferritin level estimation may be workable tests to differentiate the patients with IDA and ACD in RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Eman Tariq& Jabbar, Azza Sajed& Mohammed, Ali Nazar. 2019. A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia. Anemia،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1121515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Eman Tariq…[et al.]. A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia. Anemia No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1121515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Eman Tariq& Jabbar, Azza Sajed& Mohammed, Ali Nazar. A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia. Anemia. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1121515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1121515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر