Effects of Acute Toluene Toxicity on Different Regions of Rabbit Brain
المؤلفون المشاركون
Yoldas, Atilla
Demır, Mehmet
Cicek, Mustafa
Eser, Nadire
Sısman, Turgay
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The acute phase effects of toluene on the brain have been investigated in this study using rabbit brain via histopathological, immunohistochemical, and biochemical methods.
A total of 20 male rabbits were used as control and experimental groups.
Moreover, nerve growth factor (NGF), tumor necrosis factor-alpha (TNF-alpha), dopamine (DA), and glial fibrillary acidic protein (GFAP) tests were performed in order to designate the severity of the biochemical damage.
In the biochemical evaluation of the prefrontal cortex, hippocampus, hypothalamus, substantia nigra, and entorhinal cortex, the TNF-alpha levels in the brain were found to be significantly higher than in the control group.
Levels of dopamine, secreted from the substantia nigra, nerve growth factor (NGF) developed from the hippocampal neurons, and GFAP, secreted from astrocyte cells, were detected to be significantly lower in the toluene-administration group than in the control group (p<0.05).
In addition, areas of focal vacuolar degeneration (abscess formation), gliosis, and perivascular demyelination, many pyknotic cells and necrosis were observed.
In the toluene-administration group compared to the control group, distinct excessive expansions of the blood vessels and severe degeneration in the structure of cells and also dispersed cell borders were observed.
Furthermore, abnormal malformations of the nuclei structure of the oligodendrocyte cells were seen.
Bodies of the sequential neurons of the hippocampus in the toluene-administration group were distinctly structurally damaged compared to the control group.
In addition, cytoplasm of the cortex cell showed serious immune reactivity in the experimental group.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Demır, Mehmet& Cicek, Mustafa& Eser, Nadire& Yoldas, Atilla& Sısman, Turgay. 2017. Effects of Acute Toluene Toxicity on Different Regions of Rabbit Brain. Analytical Cellular Pathology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1121703
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Demır, Mehmet…[et al.]. Effects of Acute Toluene Toxicity on Different Regions of Rabbit Brain. Analytical Cellular Pathology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1121703
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Demır, Mehmet& Cicek, Mustafa& Eser, Nadire& Yoldas, Atilla& Sısman, Turgay. Effects of Acute Toluene Toxicity on Different Regions of Rabbit Brain. Analytical Cellular Pathology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1121703
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1121703
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر