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Different Cytokine and Chemokine Expression Patterns in Malignant Compared to Those in Nonmalignant Renal Cells
المؤلفون المشاركون
Stope, Matthias
Mustea, Alexander
Brandenburg, Lars-Ove
Gelbrich, Nadine
Ahrend, Hannes
Kaul, Anne
Zimmermann, Uwe
Burchardt, Martin
Gümbel, Denis
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Cytokines and chemokines are widely involved in cancer cell progression and thus represent promising candidate factors for new biomarkers.
Methods.
Four renal cell cancer (RCC) cell lines (Caki-1, 786-O, RCC4, and A498) and a nonmalignant renal cell line (RC-124) were examined with respect to their proliferation.
The cytokine and chemokine expression pattern was examined by a DNA array (Human Cytokines & Chemokines RT2 Profiler PCR Array; Qiagen, Hilden, Germany), and expression profiles were compared.
Results.
Caki-1 and 786-O cells exhibited significantly increased proliferation rates, whereas RCC4 and A498 cells demonstrated attenuated proliferation, compared to nonmalignant RC-124 cells.
Expression analysis revealed 52 cytokines and chemokines primarily involved in proliferation and inflammation and differentially expressed not only in malignant and nonmalignant renal cells but also in the four RCC cell lines.
Conclusion.
This is the first study examining the expression of 84 cytokines and chemokines in four RCC cell lines compared to that in a nonmalignant renal cell line.
VEGFA, NODAL, and BMP6 correlated with RCC cell line proliferation and, thus, may represent putative clinical biomarkers for RCC progression as well as for RCC diagnosis and prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gelbrich, Nadine& Ahrend, Hannes& Kaul, Anne& Brandenburg, Lars-Ove& Zimmermann, Uwe& Mustea, Alexander…[et al.]. 2017. Different Cytokine and Chemokine Expression Patterns in Malignant Compared to Those in Nonmalignant Renal Cells. Analytical Cellular Pathology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1121717
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gelbrich, Nadine…[et al.]. Different Cytokine and Chemokine Expression Patterns in Malignant Compared to Those in Nonmalignant Renal Cells. Analytical Cellular Pathology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1121717
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gelbrich, Nadine& Ahrend, Hannes& Kaul, Anne& Brandenburg, Lars-Ove& Zimmermann, Uwe& Mustea, Alexander…[et al.]. Different Cytokine and Chemokine Expression Patterns in Malignant Compared to Those in Nonmalignant Renal Cells. Analytical Cellular Pathology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1121717
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1121717
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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