Ingestion of Lycosome L-tug Formulation of Dark Chocolate Ameliorates Postprandial Hyperlipidemia and Hyperglycemia in Healthy Volunteers
المؤلفون المشاركون
Klochkov, Victor A.
Chalyk, Natalia E.
Pristenskiy, Dmitry V.
Chernyshova, Marina P.
Petyaev, Ivan M.
Kyle, Nigel
المصدر
Advances in Preventive Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Twenty-eight healthy middle-aged volunteers (40-60 years old) with equal gender representation were randomized into 3 study groups to investigate the changes in postprandial glucose and lipids after ingestion of different formulations of dark chocolate (DC).
The volunteers from the first group were requested to ingest 100 g of regular DC whereas the individuals from the third group were given 100 g of highly bioavailable lycosome formulated L-tug formulation of DC containing 23.3 mg of lycopene.
A second group received a 23.3 mg lycopene capsule, a tomato-derived antioxidant carotenoid as a matching control.
Serum specimens were obtained following 30 minutes as well as 1, 2, and 3 hours after study products intake.
Ingestion of L-tug DC was accompanied by the reduced postprandial hyperglycemia with maximum difference seen at 3rd hour of the study and reduction of average AUCGluc values by 20% (P<0.05) as compared to regular DC.
Moreover, ingestion of L-tug DC was accompanied by a statistically significantly reduced median concentration for postprandial triglycerides (to 390.7 mg⁎hr/dL; 5/95%% CIs: 363.2/405.7 versus regular DC value of 439.5mg⁎hr/dL and a lower range of confidence intervals - 5/95%CIs: 394.0/475.1).
A similar tendency was observed in changes of total cholesterol concentration.
Ingestion of L-tug DC completely abolished total cholesterol increase seen in volunteers at 3rd hour of postprandial period following intake of the control DC.
Ingestion of lycopene alone did not cause any changes in postprandial changes of glucose or serum lipids.
The observed postprandial changes can be related to the 56.2 % increase in serum lycopene level which was observed after ingestion of L-tug DC only.
Higher serum lycopene levels following the ingestion of L-tug DC resulted in a corresponding increase in serum antioxidant capacity and reduction of oxidized LDL as well as a decline in malonic dialdehyde concentration in the serum of volunteers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Petyaev, Ivan M.& Chalyk, Natalia E.& Klochkov, Victor A.& Pristenskiy, Dmitry V.& Chernyshova, Marina P.& Kyle, Nigel. 2019. Ingestion of Lycosome L-tug Formulation of Dark Chocolate Ameliorates Postprandial Hyperlipidemia and Hyperglycemia in Healthy Volunteers. Advances in Preventive Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1121771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Petyaev, Ivan M.…[et al.]. Ingestion of Lycosome L-tug Formulation of Dark Chocolate Ameliorates Postprandial Hyperlipidemia and Hyperglycemia in Healthy Volunteers. Advances in Preventive Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1121771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Petyaev, Ivan M.& Chalyk, Natalia E.& Klochkov, Victor A.& Pristenskiy, Dmitry V.& Chernyshova, Marina P.& Kyle, Nigel. Ingestion of Lycosome L-tug Formulation of Dark Chocolate Ameliorates Postprandial Hyperlipidemia and Hyperglycemia in Healthy Volunteers. Advances in Preventive Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1121771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1121771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر