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Subparalyzing Doses of Rocuronium Reduce Muscular Endurance without Detectable Effect on Single Twitch Height in Awake Subjects
المؤلفون المشاركون
Gelberg, Jan
Bentzer, Peter
Grubb, David
المصدر
Anesthesiology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
To test the hypothesis that a low-dose rocuronium acts mainly by means of reducing muscular endurance rather than by reducing momentary force.
Methods.
In a randomized placebo-controlled double-blinded study, eight healthy volunteers were studied in two sets of experiments.
In the first set, the subjects made a sustained maximum effort with the dominant hand for 80 seconds while squeezing an electronic handgrip dynamometer at three minutes after intravenous administration of placebo, 0.04 or 0.08 mg/kg rocuronium.
Handgrip force at initiation of testing (maximum handgrip force) and after 60 seconds was evaluated.
In the second set, the ulnar nerve of the subjects was electrically stimulated every tenth second for at least 10 and a maximum of 30 minutes following the administration of placebo and 0.08 mg/kg rocuronium.
Single twitch height of the adductor pollicis muscle was recorded.
Results.
There was no significant difference in the effect on maximum handgrip force at time 0 between the three different doses of rocuronium.
As compared with placebo, handgrip force after 0.08 mg/kg rocuronium was reduced to approximately a third at 60 seconds (214 N (120–278) vs.
69 (30–166); p=0.008), whereas only a slight reduction was seen after 0.04 mg/kg (187 (124–256); p=0.016).
Based on these results, the sustained handgrip force after 0.2 mg/kg at 60 seconds was calculated to be 1.27% (95% CI [0.40, 4.03]) of the maximum force of placebo.
No effect on single twitch height after 0.08 mg/kg rocuronium at four minutes after drug administration could be detected.
Conclusions.
Subparalyzing doses of rocuronium show a distinct effect on muscular endurance as opposed to momentary force.
The findings support the hypothesis that low doses of rocuronium act mainly by reducing muscular endurance, thereby facilitating, for example, tracheal intubation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gelberg, Jan& Bentzer, Peter& Grubb, David. 2019. Subparalyzing Doses of Rocuronium Reduce Muscular Endurance without Detectable Effect on Single Twitch Height in Awake Subjects. Anesthesiology Research and Practice،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1122276
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gelberg, Jan…[et al.]. Subparalyzing Doses of Rocuronium Reduce Muscular Endurance without Detectable Effect on Single Twitch Height in Awake Subjects. Anesthesiology Research and Practice No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1122276
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gelberg, Jan& Bentzer, Peter& Grubb, David. Subparalyzing Doses of Rocuronium Reduce Muscular Endurance without Detectable Effect on Single Twitch Height in Awake Subjects. Anesthesiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1122276
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1122276
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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