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Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90 % of HIV-Infected Individuals
المؤلفون المشاركون
Nakanjako, Damalie
Ingabire, Prossie Merab
Semitala, Fred
Kamya, Moses R.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Combination antiretroviral therapy (cART) initiation in hospital settings, where individuals often present with undiagnosed, untreated, advanced HIV disease, is not well understood.
Methods.
A cross-sectional study was conducted to determine a period prevalence of cART initiation within two weeks of eligibility, as determined at hospitalization.
Using a pretested and precoded data extraction tool, data on cART initiation status and reason for not initiating cART was collected.
Phone calls were made to patients that had left the hospital by the end of the two-week period.
Delayed cART initiation was defined as failure to initiate cART within two weeks.
Sociodemographic characteristics, WHO clinical stage, CD4 count, cART initiation status, and reasons for delayed cART initiation were extracted and analyzed.
Results.
Overall, 386 HIV-infected adults were enrolled, of whom 289/386 (74.9%) had delayed cART initiation, 77/386 (19.9%) initiated cART, and 20/386 (5.2%) were lost-to-follow-up, within two weeks of cART eligibility.
Of 289 with delayed ART initiation, 94 (32.5%) died within two weeks of cART eligibility.
Patients with a CD4 cell count≥ 50 cells/μl and who resided in ≥8 kilometers from the hospital were more likely to have delayed cART initiation [adjusted odds ratio (AOR) 2.34, 95% CI: 1.33-4.10, p value 0.003; and AOR 1.92, 95% CI: 1.09-3.40, p value 0.025; respectively].
Conclusion.
Up to 75% of hospitalized HIV-infected, cART-naïve, cART-eligible patients did not initiate cART and had a 33% pre-ART mortality rate within two weeks of eligibility for cART.
Hospital based strategies to hasten cART initiation during hospitalization and electronic patient tracking systems could promote active linkage to HIV treatment programs, to prevent HIV/AIDS-associated mortality in resource-limited settings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ingabire, Prossie Merab& Semitala, Fred& Kamya, Moses R.& Nakanjako, Damalie. 2019. Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90 % of HIV-Infected Individuals. AIDS Research and Treatment،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1122334
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ingabire, Prossie Merab…[et al.]. Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90 % of HIV-Infected Individuals. AIDS Research and Treatment No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1122334
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ingabire, Prossie Merab& Semitala, Fred& Kamya, Moses R.& Nakanjako, Damalie. Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90 % of HIV-Infected Individuals. AIDS Research and Treatment. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1122334
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1122334
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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