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Synthesis of Two Novel Homologous Polyphosphoesters Containing Aminophosphonate Units and Cytotoxicity of Some Low-Molecular and Polymeric Aminophosphonate Derivatives
المؤلفون المشاركون
Momekov, Georgi
Kraicheva, Ivanka
Mihaylova, Rositsa
Topashka-Ancheva, Margarita
Tsacheva, Ivelina
Stoineva, Ivanka
Vodenicharova, Elitsa
Nedialkov, Paraskev
المصدر
Advances in Materials Science and Engineering
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-13
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Two novel polyphosphoesters containing anthracene- and furan-derived aminophosphonate moieties, namely, poly[oxyethylene(aminophosphonate-co-H-phosphonate)]s P-12 and P-13, were synthesized through an addition of poly(oxyethylene H-phosphonate) to 9-anthrylidene-furfurylamine and characterized.
The novel polyphosphoester P-12 and a series of previously described anthracene-derived compounds including Schiff bases S-1 and S-2, α-aminophosphonates A-3–A-6, bis-aminophosphonate B-6, two enantiomers A-5a and A-5b, and polyphosphoesters P-8–P-11 containing aminophosphonate units were screened for antitumor activity against a panel of human leukemic cell lines, using cisplatin as a reference cytotoxic agent.
As concluded from the cytotoxicity assays, both precursors S-1 and S-2 presented similar cytotoxicity profiles that are cisplatin-like only in the REH cell line.
Leader compound of the α-aminophosphonates is A-4 with cell death-inducing properties fully equaling those of the referent drug in all of the screened leukemic cell lines with the only exception being the AML histological subtype HL-60.
Some of the polymeric analogues elicited moderate (P-10 and P-12) to low (P-11) cytotoxic activity, whereas the polyphosphoesters P-8 and P-9 produced in vitro antitumor effects largely surpassing cisplatin’s.
The compounds P-8, P-9, and A-4 could be potential new materials for anticancer therapeutic purposed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kraicheva, Ivanka& Momekov, Georgi& Mihaylova, Rositsa& Topashka-Ancheva, Margarita& Tsacheva, Ivelina& Stoineva, Ivanka…[et al.]. 2018. Synthesis of Two Novel Homologous Polyphosphoesters Containing Aminophosphonate Units and Cytotoxicity of Some Low-Molecular and Polymeric Aminophosphonate Derivatives. Advances in Materials Science and Engineering،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1122446
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kraicheva, Ivanka…[et al.]. Synthesis of Two Novel Homologous Polyphosphoesters Containing Aminophosphonate Units and Cytotoxicity of Some Low-Molecular and Polymeric Aminophosphonate Derivatives. Advances in Materials Science and Engineering No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1122446
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kraicheva, Ivanka& Momekov, Georgi& Mihaylova, Rositsa& Topashka-Ancheva, Margarita& Tsacheva, Ivelina& Stoineva, Ivanka…[et al.]. Synthesis of Two Novel Homologous Polyphosphoesters Containing Aminophosphonate Units and Cytotoxicity of Some Low-Molecular and Polymeric Aminophosphonate Derivatives. Advances in Materials Science and Engineering. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1122446
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1122446
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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