![](/images/graphics-bg.png)
Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders
المؤلفون المشاركون
Yadav, Ruchi
Srivastava, Prachi
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Neuronal developmental disorder is a class of diseases in which there is impairment of the central nervous system and brain function.
The brain in its developmental phase undergoes tremendous changes depending upon the stage and environmental factors.
Neurodevelopmental disorders include abnormalities associated with cognitive, speech, reading, writing, linguistic, communication, and growth disorders with lifetime effects.
Computational methods provide great potential for betterment of research and insight into the molecular mechanism of diseases.
In this study, we have used four samples of microarray neuronal developmental data: control, RV (resveratrol), NGF (nerve growth factor), and RV + NGF.
By using computational methods, we have identified genes that are expressed in the early stage of neuronal development and also involved in neuronal diseases.
We have used MeV application to cluster the raw data using distance metric Pearson correlation coefficient.
Finally, 60 genes were selected on the basis of coexpression analysis.
Further pathway analysis was done using the Metascape tool, and the biological process was studied using gene ontology database.
A total of 13 genes AKT1, BAD, BAX, BCL2, BDNF, CASP3, CASP8, CASP9, MYC, PIK3CD, MAPK1, MAPK10, and CYCS were identified that are common in all clusters.
These genes are involved in neuronal developmental disorders and cancers like colorectal cancer, apoptosis, tuberculosis, amyotrophic lateral sclerosis (ALS), neuron death, and prostate cancer pathway.
A protein-protein interaction study was done to identify proteins that belong to the same pathway.
These genes can be used to design potential inhibitors against neurological disorders at the early stage of neuronal development.
The microarray samples discussed in this publication are part of the data deposited in NCBI’s Gene Expression Omnibus (Yadav et al., 2018) and are accessible through GEO Series (accession number GSE121261).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yadav, Ruchi& Srivastava, Prachi. 2018. Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1122766
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yadav, Ruchi& Srivastava, Prachi. Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders. Advances in Pharmacological and Pharmaceutical Sciences No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1122766
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yadav, Ruchi& Srivastava, Prachi. Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders. Advances in Pharmacological and Pharmaceutical Sciences. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1122766
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1122766
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)