Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer
المؤلفون المشاركون
Bellare, Jayesh
Ghosh, Sougata
Joshi, Komal A.
Kitture, Rohini
Rokade, Shalaka S.
Mahajan, Ketakee
Patil, Saniya
Tomar, Geetanjali
Dubal, Dnyanesh S.
Parihar, Vijay Singh
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade.
Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal plant Gloriosa superba tuber extract (GSTE).
The synthesis of the nanoparticles was completed within 5 hours at 100°C which was confirmed by development of dark brown and black colour for PtNPs and PdNPs, respectively, along with enhancement of the peak intensity in the UV-visible spectra.
High-resolution transmission electron microscopy (HRTEM) showed that the monodispersed spherical nanoparticles were within a size range below 10 nm.
Energy dispersive spectra (EDS) confirmed the elemental composition, while dynamic light scattering (DLS) helped to evaluate the hydrodynamic size of the particles.
Anticancer activity against MCF-7 (human breast adenocarcinoma) cell lines was evaluated using MTT assay, flow cytometry, and confocal microscopy.
PtNPs and PdNPs showed 49.65 ± 1.99% and 36.26 ± 0.91% of anticancer activity.
Induction of apoptosis was most predominant in the underlying mechanism which was rationalized by externalization of phosphatidyl serine and membrane blebbing.
These findings support the efficiency of phytogenic fabrication of nanoscale platinum and palladium drugs for management and therapy against breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rokade, Shalaka S.& Joshi, Komal A.& Mahajan, Ketakee& Patil, Saniya& Tomar, Geetanjali& Dubal, Dnyanesh S.…[et al.]. 2018. Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1123160
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rokade, Shalaka S.…[et al.]. Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1123160
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rokade, Shalaka S.& Joshi, Komal A.& Mahajan, Ketakee& Patil, Saniya& Tomar, Geetanjali& Dubal, Dnyanesh S.…[et al.]. Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1123160
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123160
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر