Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies
المؤلفون المشاركون
El-Metwaly, Nashwa M.
Al-Hazmi, Gamil A.
Abou-Melha, Khlood S.
Saleh, Kamel A.
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-06
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
A series of perimidine derivatives (L1–5) were prepared and characterized by IR, 1H·NMR, mass spectroscopy, UV-Vis, XRD, thermal, and SEM analysis.
Five VO(II) complexes were synthesized and investigated by most previous tools besides the theoretical usage.
A neutral tetradentate mode of bonding is the general approach for all binding ligands towards bi-vanadyl atoms.
A square-pyramidal is the configuration proposed for all complexes.
XRD analysis introduces the nanocrystalline nature of the ligand while the amorphous appearance of its metal ion complexes.
The rocky shape is the observable surface morphology from SEM images.
Thermal analysis verifies the presence of water of crystallization with all coordination spheres.
The optimization process was accomplished using the Gaussian 09 software by different methods.
The most stable configurations were extracted and displayed.
Essential parameters were computed based on frontier energy gaps with all compounds.
QSAR parameters were also obtained to give another side of view about the biological approach with the priority of the L3 ligand.
Applying AutoDockTools 4.2 program over all perimidine derivatives introduces efficiency against 4c3p protein of breast cancer.
Antitumor activity was screened for all compounds by a comparative view over breast, colon, and liver carcinoma cell lines.
IC50 values represent promising efficiency of the L4-VO(II) complex against breast, colon, and liver carcinoma cell lines.
The binding efficiency of ligands towards CT-DNA was tested.
Binding constant (Kb) values are in agreement with the electron-drawing character of the p-substituent which offers high Kb values.
Also, variable Hammett’s relations were drawn.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Hazmi, Gamil A.& Abou-Melha, Khlood S.& El-Metwaly, Nashwa M.& Saleh, Kamel A.. 2018. Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-22.
https://search.emarefa.net/detail/BIM-1123189
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Hazmi, Gamil A.…[et al.]. Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-22.
https://search.emarefa.net/detail/BIM-1123189
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Hazmi, Gamil A.& Abou-Melha, Khlood S.& El-Metwaly, Nashwa M.& Saleh, Kamel A.. Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-22.
https://search.emarefa.net/detail/BIM-1123189
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123189
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر