Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications
المؤلفون المشاركون
Abebe, Atakilt
Atlabachew, Minaleshewa
Liyew, Misganaw
Ferede, Elsabet
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
New organic salts were synthesized by quaternizing 1,10-phenanthroline using 1-bromotetradecane.
The first step yielded an organic salt of formula [C26H37N2]Br.
Anion exchange reaction using Li[(CF3SO2)2N] resulted in a more stable salt of formula [C26H37N2][(CF3SO2)2N].
The organic salts were investigated by spectrometry (1H, 13C, 19F NMR, X-ray photoelectron spectroscopy (XPS), UV-Vis, and matrix-assisted laser desorption/ionization mass spectroscopy (MALDI MS), CHNSBr elemental analysis, and thermal analysis (TGA and DSC).
The thermal characterization showed the melting and decomposition points of [C26H37N2][(CF3SO2)2N] to be 48°C and 290°C, respectively, which indicates it is an ionic liquid with large liquidus range.
The biological activities of the salts were investigated against two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and two Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria, and they are found to be active against all of them.
They were compared with [Cu(1,10-phenanthroline)2Cl]Cl.
They are found more active against the Gram-negative bacteria.
The salts demonstrated minimum inhibitory concentration as low as 50 µg/L.
These results suggest the synthesized salts can be considered as a better alternative to certain transition metal complex drugs.
This minimizes the concern of introducing metal ions into the organism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abebe, Atakilt& Atlabachew, Minaleshewa& Liyew, Misganaw& Ferede, Elsabet. 2018. Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1123208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abebe, Atakilt…[et al.]. Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1123208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abebe, Atakilt& Atlabachew, Minaleshewa& Liyew, Misganaw& Ferede, Elsabet. Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1123208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر