Hematologic Markers as Prognostic Factors in Nonmetastatic Esophageal Cancer Patients under Concurrent Chemoradiotherapy
المؤلفون المشاركون
Wu, Yi-Feng
Chu, Sung-Chao
Chang, Bee-Song
Cheng, Yi-Tso
Wang, Tso-Fu
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Nonmetastatic esophageal cancer can demonstrate a high local recurrence rate even under the standard treatment.
We evaluated platelet counts before and after concurrent chemoradiotherapy (CCRT), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio for predicting esophageal cancer prognosis under CCRT.
Newly diagnosed patients with esophageal cancer (stages IA–IIIC) who underwent CCRT during January 2013–December 2017 were enrolled.
The data were collected retrospectively.
Overall survival (OS), time to progressive disease (TPD), and time to metastasis (TM) were recorded for indicating prognosis.
Kaplan–Meier curves were plotted and univariate and multivariate analyses were performed.
In total, 105 patients were enrolled.
The stages of esophageal cancer and surgery were associated with prognosis (i.e., OS, TPD, and TM).
Based on TPD and TM, women had better prognosis than men.
In the univariate analysis, high pre- and post-CCRT platelet counts (>300,000/μL), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) as well as low lymphocyte percentage were significantly associated with poor prognosis.
However, in the multivariate analysis, only post-CCRT high platelet count (>300,000/μL) remained significantly associated with poor prognosis (P = .041, .045, and .023 for OS, TPD, and TM, respectively).
Poor prognosis was observed in patients with high platelet counts, PLR, NLR, and low lymphocyte percentage.
Surgery was an independent factor predicting better prognosis.
Our findings may have clinical significance with regard to therapeutic decision-making.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Yi-Feng& Chu, Sung-Chao& Chang, Bee-Song& Cheng, Yi-Tso& Wang, Tso-Fu. 2019. Hematologic Markers as Prognostic Factors in Nonmetastatic Esophageal Cancer Patients under Concurrent Chemoradiotherapy. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123224
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Yi-Feng…[et al.]. Hematologic Markers as Prognostic Factors in Nonmetastatic Esophageal Cancer Patients under Concurrent Chemoradiotherapy. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1123224
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Yi-Feng& Chu, Sung-Chao& Chang, Bee-Song& Cheng, Yi-Tso& Wang, Tso-Fu. Hematologic Markers as Prognostic Factors in Nonmetastatic Esophageal Cancer Patients under Concurrent Chemoradiotherapy. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123224
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123224
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر