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Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA)
المؤلفون المشاركون
Musarrat, Javed
Al-Khedhairy, Abdulaziz A.
Al-Massarani, Shaza M.
Siddiqui, Maqsood A.
Al-Sheddi, Ebtesam S.
Farshori, Nida N.
Al-Oqail, Mai M.
Saquib, Quaiser
Wahab, Rizwan
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In this study, silver nanoparticles (AgNPs) were synthesized using aqueous extract of Nepeta deflersiana plant.
The prepared AgNPs (ND-AgNPs) were examined by ultraviolet-visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscope (SEM), and energy dispersive spectroscopy (EDX).
The results obtained from various characterizations revealed that average size of synthesized AgNPs was 33 nm and in face-centered-cubic structure.
The anticancer potential of ND-AgNPs was investigated against human cervical cancer cells (HeLa).
The cytotoxic response was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), neutral red uptake (NRU) assays, and morphological changes.
Further, the influence of cytotoxic concentrations of ND-AgNPs on oxidative stress markers, reactive oxygen species (ROS) generation, mitochondrial membrane potential (MMP), cell cycle arrest and apoptosis/necrosis was studied.
The cytotoxic response observed was in a concentration-dependent manner.
Furthermore, the results also showed a significant increase in ROS and lipid peroxidation (LPO), along with a decrease in MMP and glutathione (GSH) levels.
The cell cycle analysis and apoptosis/necrosis assay data exhibited ND-AgNPs-induced SubG1 arrest and apoptotic/necrotic cell death.
The biosynthesized AgNPs-induced cell death in HeLA cells suggested the anticancer potential of ND-AgNPs.
Therefore, they may be used to treat the cervical cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Sheddi, Ebtesam S.& Farshori, Nida N.& Al-Oqail, Mai M.& Al-Massarani, Shaza M.& Saquib, Quaiser& Wahab, Rizwan…[et al.]. 2018. Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA). Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1123232
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Sheddi, Ebtesam S.…[et al.]. Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA). Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1123232
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Sheddi, Ebtesam S.& Farshori, Nida N.& Al-Oqail, Mai M.& Al-Massarani, Shaza M.& Saquib, Quaiser& Wahab, Rizwan…[et al.]. Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA). Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1123232
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123232
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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