Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis

المؤلفون المشاركون

Miao, Guiqiang
Zang, Xuehui
Hou, Huige
Sun, Hui
Wang, Lihui
Zhang, Ting
Tan, Yongtao
Liu, Wenzhou
Ye, Pei
Gao, Lihua
Zha, Zhengang

المصدر

BioMed Research International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-03-12

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Osteoarthritis (OA) is a chronic degenerative joint disease, where chondrocyte apoptosis is responsible for cartilage degeneration.

Bax is a well-known proapoptotic protein of the Bcl-2 family, involved in a large number of physiological and pathological processes.

However, the regulation mechanisms of Bax underlying chondrocyte apoptosis in OA remain unknown.

In the present study, we determined the role of Bax in human OA and chondrocyte apoptosis.

The results showed that Bax was upregulated in chondrocytes from the articular cartilage of OA patients and in cultured chondrocyte-like ATDC5 cells treated by IL-1β.

Bax was identified to be the direct target of miR-29a by luciferase reporter assay and by western blotting.

Inhibition of miR-29a by the mimics protested and overexpression by miR-29a inhibitors aggravated ATDC5 apoptosis induced by IL-1β.

These data reveal that miR-29a/Bax axis plays an important role in regulating chondrocyte apoptosis and suggest that targeting the proapoptotic protein Bax and increasing expression levels of miR-29a emerge as potential approach for protection against the development of OA.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Miao, Guiqiang& Zang, Xuehui& Hou, Huige& Sun, Hui& Wang, Lihui& Zhang, Ting…[et al.]. 2019. Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123356

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Miao, Guiqiang…[et al.]. Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123356

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Miao, Guiqiang& Zang, Xuehui& Hou, Huige& Sun, Hui& Wang, Lihui& Zhang, Ting…[et al.]. Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123356

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1123356