miR-451 Silencing Inhibited Doxorubicin Exposure-Induced Cardiotoxicity in Mice
المؤلفون المشاركون
Li, Jun
Wan, Weiguo
Chen, Tao
Tong, Suiyang
Jiang, Xuejun
Liu, Wanli
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Oxidative stress and cardiomyocytes apoptosis were closely involved in the pathological process of doxorubicin- (Dox-) induced cardiac injury.
MicroRNA-451 (miR-451) was mainly expressed in cardiomyocytes.
However, the role of miR-451 in Dox-induced cardiac injury remained unclear.
Our study aimed to investigate the effect of miR-451 on Dox-induced cardiotoxicity in mice.
We established a Dox-induced cardiotoxicity model in the mice and manipulated miR-451 expression in the heart using a miR-451 inhibitor, which was injected every other day beginning at one day before Dox injection.
Oxidative stress and apoptosis in the hearts were evaluated.
miR-451 levels were significantly increased in Dox-treated mice or cardiomyocytes.
miR-451 inhibition attenuated Dox-induced whole-body wasting and heart atrophy, reduced cardiac injury, restored cardiac function, and improved cardiomyocyte contractile function.
Moreover, miR-451 inhibition reduced oxidative stress and cardiomyocytes apoptosis in vivo and in vitro.
miR-451 inhibition increased the expression of calcium binding protein 39 (Cab39) and activated adenosine monophosphate activated protein kinase (AMPK) signaling pathway.
A specific inhibitor of AMPK abolished the protection provided by miR-451 inhibition against cell injury in vitro.
In conclusion, miR-451 inhibition protected against Dox-induced cardiotoxicity via activation of AMPK signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jun& Wan, Weiguo& Chen, Tao& Tong, Suiyang& Jiang, Xuejun& Liu, Wanli. 2019. miR-451 Silencing Inhibited Doxorubicin Exposure-Induced Cardiotoxicity in Mice. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123404
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jun…[et al.]. miR-451 Silencing Inhibited Doxorubicin Exposure-Induced Cardiotoxicity in Mice. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1123404
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jun& Wan, Weiguo& Chen, Tao& Tong, Suiyang& Jiang, Xuejun& Liu, Wanli. miR-451 Silencing Inhibited Doxorubicin Exposure-Induced Cardiotoxicity in Mice. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123404
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123404
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر