Gender-Related Effect of Sodium Dichloroacetate on the Number of Hassall’s Corpuscles and RNA NKCC1 Expression in Rat Thymus

المؤلفون المشاركون

Balnytė, Ingrida
Valančiūtė, Angelija
Lesauskaite, Vaiva
Stanevičiūtė, Jūratė
Juknevičienė, Milda
Fadejeva, Julija
Stakauskas, Rimantas
Stakišaitis, Donatas

المصدر

BioMed Research International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-04-24

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الملخص EN

The aim was to investigate the effect of dichloroacetate (DCA) on thymus weight, Hassall’s corpuscle number (HCs), and NKCC1 RNA expression in Wistar rats aged 4–5 weeks.

They were investigated in the controls and DCA-treated gonad-intact and castrated males and females.

The treatment lasted 4 weeks with DCA 200 mg/kg/day.

At the end of the experiment, rat thymus was weighted, and its lobe was taken for the expression of NKCC1 RNA determined by the PCR method and of Hassall’s corpuscles by immunohistochemistry.

DCA caused a thymus weight decrease in DCA-treated gonad-intact rats of both genders as compared with their controls (p < 0.05), and no such impact was found in castrated DCA-treated males and females.

DCA caused an increase of the HCs in gonad-intact males (p < 0.05), and no such increase in the DCA-treated gonad-intact females was found.

There was gender-related difference in the HCs when comparing DCA-treated gonad-intact males and females: males showed significantly higher HCs (p < 0.05); no gender-related differences were found in the castrated DCA-treated groups.

The Slc12a2 gene RNA expression level was found to be significantly decreased only in gonad-intact and in castrated DCA-treated males.

The authors discuss the gender-related DCA effects on the thymus.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Stanevičiūtė, Jūratė& Juknevičienė, Milda& Balnytė, Ingrida& Valančiūtė, Angelija& Lesauskaite, Vaiva& Fadejeva, Julija…[et al.]. 2019. Gender-Related Effect of Sodium Dichloroacetate on the Number of Hassall’s Corpuscles and RNA NKCC1 Expression in Rat Thymus. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123427

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Stanevičiūtė, Jūratė…[et al.]. Gender-Related Effect of Sodium Dichloroacetate on the Number of Hassall’s Corpuscles and RNA NKCC1 Expression in Rat Thymus. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1123427

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Stanevičiūtė, Jūratė& Juknevičienė, Milda& Balnytė, Ingrida& Valančiūtė, Angelija& Lesauskaite, Vaiva& Fadejeva, Julija…[et al.]. Gender-Related Effect of Sodium Dichloroacetate on the Number of Hassall’s Corpuscles and RNA NKCC1 Expression in Rat Thymus. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123427

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1123427