Clinical Features and Cytokine Profile in Myositis Patients with Anti-EJ Autoantibodies Detected by a Novel Immunoprecipitation Assay
المؤلفون المشاركون
Yang, Yang
Liu, Yangtengyu
Huang, Li
Wang, Li
Liu, Ke
Liu, Meidong
Luo, Hui
Zuo, Xiaoxia
Li, Yisha
Zhang, Huali
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
This study aimed to clarify the clinical features, the serum level of autoantibodies, and cytokine of myositis patients with anti-EJ antibody, which targets glycyl tRNA-synthetase (GlyRS).
Methods.
Sera of 236 Chinese patients with myositis were screened for anti-EJ by a novel immunoprecipitation assay of flag-tagged GlyRS.
Anti-EJ positive patients are evaluated for the clinical features and cytokine profile.
Results.
The sera from 4 of 236 adult myositis patients were found to carry the anti-EJ using established novel immunoprecipitation assay and immunoblotting.
The prevalence of anti-EJ in our cohorts is about 1.7%.
The decline of anti-EJ level was detected in two patients during disease remission.
Interstitial lung disease and muscle weakness, but not skin involvement, are common clinical features of anti-EJ positive patients.
Moreover, using a cytokine profile analyses, we found that the serum levels of IP-10, IL-6, MCP-1, and VEGF were significantly elevated in patients with anti-EJ and gradually decreased during disease remission of two patients, whereas IL-8 level was obviously reduced in these patients.
Conclusion.
The novel immunoprecipitation assay is suitable to detect and monitor the levels of anti-EJ autoantibody.
The serum levels of anti-EJ, IP-10, IL-6, MCP-1, and VEGF may be related to disease activity in myositis patients with anti-EJ antibodies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Yang& Liu, Yangtengyu& Huang, Li& Wang, Li& Liu, Ke& Liu, Meidong…[et al.]. 2019. Clinical Features and Cytokine Profile in Myositis Patients with Anti-EJ Autoantibodies Detected by a Novel Immunoprecipitation Assay. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123547
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Yang…[et al.]. Clinical Features and Cytokine Profile in Myositis Patients with Anti-EJ Autoantibodies Detected by a Novel Immunoprecipitation Assay. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123547
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Yang& Liu, Yangtengyu& Huang, Li& Wang, Li& Liu, Ke& Liu, Meidong…[et al.]. Clinical Features and Cytokine Profile in Myositis Patients with Anti-EJ Autoantibodies Detected by a Novel Immunoprecipitation Assay. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123547
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123547
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر