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Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics
المؤلفون المشاركون
Yang, Fei-ran
Li, Hui-jie
Li, Ting-ting
Zhao, Yu-feng
Liu, Zong-kai
Li, Xiu-rong
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Although several studies have proved the relationship between the prognostic value of miRNA-15a and different types of cancer, the result remains controversial.
Thus, a meta-analysis was conducted to clarify the prognostic value of miRNA-15a expression level in human cancers.
Methods.
We enrolled appropriate literature by searching the databases of PubMed, Embase, and Web of Science.
Subsequently, we extracted HRs and their 95% CIs and calculated pooled results of miRNA-15a for overall survival (OS) and disease-free survival (DFS).
Besides, subgroup analysis, sensitivity analysis, and publication bias were also revealed in this study.
We also further validated this meta-analysis using the Kaplan-Meier plotter database.
Result.
10 studies, including 1616 patients, were embraced in our meta-analysis.
The result showed the lower expression of miRNA-15a significantly predicted adverse OS (HR=2.17, 95% CI: 1.41-3.34), but there is no significant association between the expressing level and DFS in cancer patient (HR=2.04, 95% CI: 0.60-6.88).
Based on Kaplan-Meier plotter database, we found the same results in bladder Carcinoma, head-neck squamous cell carcinoma, liver hepatocellular carcinoma, lung squamous cell carcinoma, pancreatic ductal adenocarcinoma, rectum adenocarcinoma, stomach adenocarcinoma, and uterine corpus endometrial carcinoma, but opposite results were found in cervical squamous cell carcinoma and esophageal carcinoma.
Conclusion.
Low expressing levels of miRNA-15a indicated poor OS, while miRNA-15a can be used as a prediction biomarker in different cancer types.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Fei-ran& Li, Hui-jie& Li, Ting-ting& Zhao, Yu-feng& Liu, Zong-kai& Li, Xiu-rong. 2019. Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1123648
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Fei-ran…[et al.]. Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1123648
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Fei-ran& Li, Hui-jie& Li, Ting-ting& Zhao, Yu-feng& Liu, Zong-kai& Li, Xiu-rong. Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1123648
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123648
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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