Tumor Suppressive Function of NQO1 in Cutaneous Squamous Cell Carcinoma (SCC) Cells
المؤلفون المشاركون
Zhang, Qing-Ling
Li, Xue Mei
Lian, De-De
Zhu, Ming Ji
Yim, Su-Hyuk
Jiang, Ri-Hua
Kim, Chang-Deok
Lee, J.-H.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Cutaneous squamous cell carcinoma (SCC) is a common cancer that significantly decreases the quality of life.
It is known that external stimulus such as ultraviolet (UV) radiation induces cutaneous SCC via provoking oxidative stress.
NAD(P)H dehydrogenase 1 (NQO1) is a ubiquitous flavoenzyme that functions as a guardian against oxidative stress.
However, the effect of NQO1 on cutaneous SCC is not clearly elucidated.
In this study, we investigated the effect of NQO1 on cutaneous SCC cells using the recombinant adenoviruses that can upregulate and/or downregulate NQO1 expression.
Overexpression of NQO1 resulted in significant decrease of cell proliferation and colony forming activity of SCC lines (SCC12 and SCC13 cells).
By contrast, knockdown of NQO1 increased the cell proliferation and colony forming activity.
Accordingly, the levels of proliferation-related regulators, such as Cyclin D1, Cyclin E, PCNA, SOX2, and p63, were decreased by the overexpression of NQO1, while those were increased by knockdown of NQO1.
In addition, NQO1 affected the invasion and migration of SCC cells in a very similar way, with the regulation of epithelial-mesenchymal transition- (EMT-) related molecules, including E-cadherin, N-cadherin, Vimentin, Snail, and Slug.
Finally, the overexpression of NQO1 decreased the level of phosphorylated AKT, JNK, and p38 MAPK, while the knockdown of NQO1 increased the level of phosphorylated signaling molecules.
Based on these data, NQO1 has tumor suppressive function in cutaneous SCC cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Qing-Ling& Li, Xue Mei& Lian, De-De& Zhu, Ming Ji& Yim, Su-Hyuk& Lee, J.-H.…[et al.]. 2019. Tumor Suppressive Function of NQO1 in Cutaneous Squamous Cell Carcinoma (SCC) Cells. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123671
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Qing-Ling…[et al.]. Tumor Suppressive Function of NQO1 in Cutaneous Squamous Cell Carcinoma (SCC) Cells. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123671
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Qing-Ling& Li, Xue Mei& Lian, De-De& Zhu, Ming Ji& Yim, Su-Hyuk& Lee, J.-H.…[et al.]. Tumor Suppressive Function of NQO1 in Cutaneous Squamous Cell Carcinoma (SCC) Cells. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123671
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123671
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر