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Intestinal Immunomodulation and Shifts on the Gut Microbiota of BALBc Mice Promoted by Two Bifidobacterium and Lactobacillus Strains Isolated from Human Samples
المؤلفون المشاركون
Nogacka, Alicja M.
Oddi, Sofia
Reinheimer, Jorge A.
Vinderola, Gabriel
de los Reyes-Gavilán, Clara G.
Gueimonde, Miguel
Salazar, Nuria
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Bifidobacterium animalis subsp.
lactis IPLA 20020 and Lactobacillus gasseri IPLA 20212, two strains isolated from human samples, were evaluated for safety and influence over the intestinal microbiota and cytokine production by the intestinal tissue of adult BALB/c mice.
Mice were divided into four groups receiving during 8 days PBS or a suspension of each strain, prepared fresh or lyophilized (bifidobacteria), at an amount of 4x108 viable cells/day.
This dose could be comparable to the probiotic intake of a human adult who consumed about 100-200 mL of functional fermented milk per day, considering the usual level of probiotics in commercial products.
No microbial translocation to liver or alterations in food intake, weight, and behavior were observed in treated mice.
Intestinal content of secretory immunoglobulin A (s-IgA) was not affected, discarding any adverse effect on the mucosa-associated immunity.
The profile of intestinal proinflammatory/regulatory cytokines after intervention evidenced that the microbial strain administered and its cellular state (fresh or lyophilized) as well as the host tissue analyzed (small or large intestine) influenced the immune response and suggests a moderate shift towards a T helper 1 profile (Th1) in the large intestine after the administration of both strains.
Changes on relative levels of some intestinal microbial groups were evidenced after intervention.
It is noteworthy that butyrate was positively associated with a balanced pro-Th1 immune response.
Therefore, B.
animalis subsp.
lactis IPLA20020 and L.
gasseri IPLA 20212 could be considered potential probiotic candidates to be included in functional foods for balancing the intestinal immune response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nogacka, Alicja M.& Oddi, Sofia& Salazar, Nuria& Reinheimer, Jorge A.& Gueimonde, Miguel& Vinderola, Gabriel…[et al.]. 2019. Intestinal Immunomodulation and Shifts on the Gut Microbiota of BALBc Mice Promoted by Two Bifidobacterium and Lactobacillus Strains Isolated from Human Samples. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nogacka, Alicja M.…[et al.]. Intestinal Immunomodulation and Shifts on the Gut Microbiota of BALBc Mice Promoted by Two Bifidobacterium and Lactobacillus Strains Isolated from Human Samples. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nogacka, Alicja M.& Oddi, Sofia& Salazar, Nuria& Reinheimer, Jorge A.& Gueimonde, Miguel& Vinderola, Gabriel…[et al.]. Intestinal Immunomodulation and Shifts on the Gut Microbiota of BALBc Mice Promoted by Two Bifidobacterium and Lactobacillus Strains Isolated from Human Samples. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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