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Cell Adhesion-Related Molecules Play a Key Role in Renal Cancer Progression by Multinetwork Analysis
المؤلفون المشاركون
Wang, Anbang
Chen, Ming
Wang, Hui
Huang, Jinming
Bao, Yi
Gan, Xinxin
Liu, Bing
Lu, Xin
Wang, Linhui
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Renal cell carcinoma (RCC) is one of the most common malignancies in the urinary system.
The study aimed to identify genetic characteristics and reveal the underlying mechanisms in RCC.
GSE53757, GSE46699, and TCGA KIRC database (n = 897) were analyzed to screen differentially expressed genes (DEGs) in RCC.
The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed, followed by the analysis of the protein-protein interaction (PPI) network of the DEGs by Cytoscape software.
In all, 834 DEGs were identified in RCC, including 416 upregulated genes and 418 downregulated genes.
The top 10 hub genes, VEGFA, EGFR, EGF, CD44, CD86, FN1, ITGAM, ITGB2, TLR2, and PTPRC, were identified from the PPI network according to the core degree.
The following subnetwork revealed that these significant modules were enriched in positive regulation of response to external stimulus, regulation of leukocyte-mediated immunity, and regulation of exocytosis.
The expressions of these hub genes were also validated using qRT-PCR and IHC in Changzheng RCC database (n = 160).
We especially found that half of the top ten hub genes were cell adhesion-related molecules, which were associated with RCC progression and poor prognosis.
In conclusion, these hub genes, particularly cell adhesion-related molecules, could be used as prognostic biomarkers and potential therapeutic targets for RCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Anbang& Chen, Ming& Wang, Hui& Huang, Jinming& Bao, Yi& Gan, Xinxin…[et al.]. 2019. Cell Adhesion-Related Molecules Play a Key Role in Renal Cancer Progression by Multinetwork Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123772
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Anbang…[et al.]. Cell Adhesion-Related Molecules Play a Key Role in Renal Cancer Progression by Multinetwork Analysis. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1123772
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Anbang& Chen, Ming& Wang, Hui& Huang, Jinming& Bao, Yi& Gan, Xinxin…[et al.]. Cell Adhesion-Related Molecules Play a Key Role in Renal Cancer Progression by Multinetwork Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123772
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123772
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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