TLR2 Arg753Gln Gene Polymorphism Associated with Tuberculosis Susceptibility: An Updated Meta-Analysis
المؤلفون المشاركون
Hu, Lelin
Tao, Huihui
Tao, Xinrong
Tang, Xiaolong
Xu, Congjing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To date, a series of studies were conducted to investigate the association between TLR2 (Toll-like receptor 2) Arg753Gln gene polymorphism and tuberculosis (TB).
However, the results were inconsistent.
This meta-analysis was performed to elucidate the roles of TLR2 Arg753Gln gene polymorphism in TB.
Methods.
All available articles were searched from online databases such as PubMed, Medline, CNKI, and Wanfang.
Statistical analyses were performed using the STATA12.0 (Stata Corp LP, College Station, TX, United States) software.
Results.
32 case-control studies comprising 5943 cases and 5991 controls were identified in this meta-analysis.
Overall, the TLR2 Arg753Gln gene polymorphism was associated with high TB risk in allele model (A vs.
G: OR=2.20, 95%CI=1.60-3.04, P≤0.01), dominant model (AA+AG vs.
GG: OR=2.70, 95%CI=2.00-3.65, P≤0.01), and heterozygote model (AG vs.
GG contrast: OR=2.97, 95%CI=2.39-3.69, P≤0.01).
Subgroup analysis by ethnicity indicated that the A allele increased susceptibility to TB in Asian (OR=3.35, 95%CI=2.36-4.74) and Caucasian populations (OR=2.62, 95%CI=1.77-3.87), but not in African (2.08, 95%CI=0.62-2.72) or mixed populations (OR=0.76, 95%CI=0.36-1.14).
Stratified analysis by sample type suggested that the A allele associated with high pulmonary tuberculosis (PTB) risks (OR=2.43, 95%CI=1.66-3.54), but not with extra pulmonary tuberculosis (EPTB) (OR=1.84, 95%CI=0.83-4.06).
Conclusion.
this meta-analysis suggested the following: (1) TLR2 Arg753Gln polymorphism is significantly associated with high TB risk.
(2) In subgroup analysis based on ethnicity, TLR2 Arg753Gln polymorphism elevates the risk of TB in Asian and Caucasian populations, but not in African or mixed populations.
(3) Stratified by sample type, TLR2 Arg753Gln polymorphism is associated with increased PTB risk, but not with EPTB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Lelin& Tao, Huihui& Tao, Xinrong& Tang, Xiaolong& Xu, Congjing. 2019. TLR2 Arg753Gln Gene Polymorphism Associated with Tuberculosis Susceptibility: An Updated Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123986
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Lelin…[et al.]. TLR2 Arg753Gln Gene Polymorphism Associated with Tuberculosis Susceptibility: An Updated Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123986
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Lelin& Tao, Huihui& Tao, Xinrong& Tang, Xiaolong& Xu, Congjing. TLR2 Arg753Gln Gene Polymorphism Associated with Tuberculosis Susceptibility: An Updated Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123986
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123986
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر