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Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor-α Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress
المؤلفون المشاركون
Ar Rochmah, Mawaddah
Harini, Ika Murti
Septyaningtrias, Dian Eurike
Sari, Dwi Cahyani Ratna
Susilowati, Rina
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Centella asiatica ameliorates memory impairment and induces expression of hippocampal brain-derived neurotropic factor (BDNF) in chronically stressed rats.
The relationship between the anti-inflammatory effect of Centella asiatica on hippocampal BDNF and the involvement of sirtuin-1, a BDNF expression regulator, in neuroprotective mechanisms of Centella asiatica warrants an investigation.
We investigated the effect of Centella asiatica ethanolic extracts (CA) on TNF-α, IL-10, and SIRT1 levels and whether these predicted BDNF expression in rat hippocampus after chronic stress.
For the experiments, thirty male rats (Sprague Dawley) were divided into six groups: nonstressed-control, stressed-control, nonstressed +CA 300mg/kg/d, stressed +CA 150 mg/kg/d, stressed +CA 300 mg/kg/d, and stressed +CA 600 mg/kg/d.
On day 28, rats were sacrificed and hippocampus was dissected out.
Hippocampal TNF-α, IL-10, SIRT1, and BDNF were measured by enzyme-linked immunosorbent assay.
Hippocampal TNF-α level was significantly higher in the stressed-control compared to nonstressed-control groups.
Across all stress conditions, rats receiving the highest dose of CA had the lowest mean TNF-α and highest mean BDNF.
There were no significant differences in IL-10 and SIRT1 levels between groups.
Hippocampal TNF-α did not predict hippocampal BDNF in a regression analysis.
In conclusion, lower TNF-α and higher BDNF in the hippocampus support the hypothesis that these factors independently contribute to Centella asiatica’s neuroprotective effect in chronically stressed rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ar Rochmah, Mawaddah& Harini, Ika Murti& Septyaningtrias, Dian Eurike& Sari, Dwi Cahyani Ratna& Susilowati, Rina. 2019. Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor-α Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1124000
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ar Rochmah, Mawaddah…[et al.]. Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor-α Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1124000
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ar Rochmah, Mawaddah& Harini, Ika Murti& Septyaningtrias, Dian Eurike& Sari, Dwi Cahyani Ratna& Susilowati, Rina. Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor-α Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1124000
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124000
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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