Assessment of the Levels of Level of Biomarkers of Bone Matrix Glycoproteins and Inflammatory Cytokines from Saudi Parkinson Patients
المؤلفون المشاركون
Alrafiah, Aziza
Al-Ofi, Ebtisam
Obaid, Mona Talib
Alsomali, Nimah
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Parkinson's disease (PD) is the second most commonly neurodegenerative disease after Alzheimer's disease which occurs to nearly 1% of the population > 50 years old.
Inflammatory and bone biomarkers have both become valuable tools for PD diagnosis and prognosis.
However, no studies have examined these markers in Saudi patients diagnosed with PD.
Objectives.
To assess the biomarkers and proinflammatory cytokines from blood with PD in serum.
Methods.
In our study, we included 26 patients with PD and 24 controls.
Blood samples were withdrawn from subjects with PD and their matched controls.
Biomarkers multiplex assay from Milliplex was used to assess the levels of IL-1B, IL-6, TNF-α, osteoprotegerin (OPG), osteopontin (OPN), and PTH (parathyroid hormone).
Data was analyzed using the Statistical Package, GraphPad Prism.
Results.
We found that IL-1ß cytokine is significantly higher in patients with PD (p value = 0.0014).
However, there are no statistically significant variances found among the two studied groups with regard to the IL-6 and TNF-α cytokines levels.
We also found that levels of PTH are decreased in the PD subjects than the age-matched controls (p value= 0.003).
Also, the bone matrix glycoproteins, including osteoprotegerin (OPG) and osteopontin (OPN), are significantly upregulated (p value= 0.04 for OPG and p value= 0.003 for OPN), as compared to the controls.
Conclusions.
Our findings are reliable with the possibility that inflammatory and bone markers can be used as biomarkers in PD prognosis.
However, to clarify the natural role and consequence of these markers in PD pathology, further larger cohort studies are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alrafiah, Aziza& Al-Ofi, Ebtisam& Obaid, Mona Talib& Alsomali, Nimah. 2019. Assessment of the Levels of Level of Biomarkers of Bone Matrix Glycoproteins and Inflammatory Cytokines from Saudi Parkinson Patients. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1124018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alrafiah, Aziza…[et al.]. Assessment of the Levels of Level of Biomarkers of Bone Matrix Glycoproteins and Inflammatory Cytokines from Saudi Parkinson Patients. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1124018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alrafiah, Aziza& Al-Ofi, Ebtisam& Obaid, Mona Talib& Alsomali, Nimah. Assessment of the Levels of Level of Biomarkers of Bone Matrix Glycoproteins and Inflammatory Cytokines from Saudi Parkinson Patients. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1124018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر