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Propranolol Treatment for Infantile Hemangiomas: Short-Term Adverse Effects and Follow-Up to Age Two
المؤلفون المشاركون
Li, Xueqing
Yang, Kun
Li, Hongwen
Huo, Ran
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To analyse the short-term adverse effects (AEs) of propranolol in the treatment of infantile hemangiomas (IHs) and their relevant factors, as well as the relationship between child growth and propranolol.
Methods.
A total of 506 patients with confirmed or suspected IHs were enrolled, and a total of 439 cases were included in the study.
Short-term AEs were analysed using single-factor analysis and binary logistic regression.
Out of 439 patients, 292 were enrolled to examine the effect of propranolol on 2-year-olds’ height and body weight (BW), by comparison with reference range and among groups.
Spearman rank correlation analysis was used to determine the relationship between BW, height, and duration of propranolol treatment.
Results.
Among 439 patients, 70 (16.0%) experienced AEs.
Among them, 48 had gastrointestinal (GI) symptoms, 23 had central nervous system (CNS) symptoms, 8 had both symptoms above, and 7 had other symptoms.
Most of the AEs occurred on the starting day (day 0), and 6 children’s AEs were transient.
Starting age of no older than 3 months led to more CNS symptoms, and starting age of older than 3 months was a protective factor against CNS symptoms, with an OR value of 0.303 (0.117–0.783).
Height and BW of 292 two-year-old children were no less than the reference levels, although those of 3 females and 1 male were less than the average −2 standard deviation (−2SD).
The height and BW of the children at the age of two was not related to the length of time of propranolol treatment.
Conclusion.
Oral propranolol has a good tolerance in the treatment of IHs.
Oral propranolol exerts more adverse effects on the CNS of lower age children, and it has exhibited no effect on the growth of two-year-old children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xueqing& Yang, Kun& Li, Hongwen& Huo, Ran. 2019. Propranolol Treatment for Infantile Hemangiomas: Short-Term Adverse Effects and Follow-Up to Age Two. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124046
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xueqing…[et al.]. Propranolol Treatment for Infantile Hemangiomas: Short-Term Adverse Effects and Follow-Up to Age Two. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1124046
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xueqing& Yang, Kun& Li, Hongwen& Huo, Ran. Propranolol Treatment for Infantile Hemangiomas: Short-Term Adverse Effects and Follow-Up to Age Two. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124046
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124046
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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