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Identification of Phosphohistone H3 Cutoff Values Corresponding to Original WHO Grades but Distinguishable in Well-Differentiated Gastrointestinal Neuroendocrine Tumors
المؤلفون المشاركون
Kim, Dong Gyu
Park, Hye-Rim
Min, Soo Kee
Kwon, Mi Jung
Kang, Ho Suk
Kim, Min Jeong
Choi, Kyung Chan
Nam, Eun Sook
Cho, Seong Jin
Choe, Ji-Young
Park, Hyoung-Chul
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Mitotic counts in the World Health Organization (WHO) grading system have narrow cutoff values.
True mitotic figures, however, are not always distinguishable from apoptotic bodies and darkly stained nuclei, complicating the ability of the WHO grading system to diagnose well-differentiated neuroendocrine tumors (NETs).
The mitosis-specific marker phosphohistone H3 (PHH3) can identify true mitoses and grade tumors reliably.
The aim of this study was to investigate the correspondence of tumor grades, as determined by PHH3 mitotic index (MI) and mitotic counts according to WHO criteria, and to determine the clinically relevant cutoffs of PHH3 MI in rectal and nonrectal gastrointestinal NETs.
Mitotic counts correlated with both the Ki-67 labeling index and PHH3 MI, but the correlation with PHH3 MI was slightly higher.
The PHH3 MI cutoff ≥4 correlated most closely with original WHO grades for both rectal NETs.
A PHH3 MI cutoff ≥4, which could distinguish between G1 and G2 tumors, was associated with disease-free survival in patients with rectal NETs, whereas that cutoff value showed marginal significance for overall survival in patient with rectal NETs.
In conclusion, the use of PHH3 ≥4 correlated most closely with original WHO grades.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Min Jeong& Kwon, Mi Jung& Kang, Ho Suk& Choi, Kyung Chan& Nam, Eun Sook& Cho, Seong Jin…[et al.]. 2018. Identification of Phosphohistone H3 Cutoff Values Corresponding to Original WHO Grades but Distinguishable in Well-Differentiated Gastrointestinal Neuroendocrine Tumors. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1124087
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Min Jeong…[et al.]. Identification of Phosphohistone H3 Cutoff Values Corresponding to Original WHO Grades but Distinguishable in Well-Differentiated Gastrointestinal Neuroendocrine Tumors. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1124087
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Min Jeong& Kwon, Mi Jung& Kang, Ho Suk& Choi, Kyung Chan& Nam, Eun Sook& Cho, Seong Jin…[et al.]. Identification of Phosphohistone H3 Cutoff Values Corresponding to Original WHO Grades but Distinguishable in Well-Differentiated Gastrointestinal Neuroendocrine Tumors. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1124087
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124087
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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