Bone Marrow Molecular Markers Associated with RelapsedRefractory Activated B-Cell-Like Diffuse Large B-Cell Lymphoma
المؤلفون المشاركون
Wang, Di
Liu, Peng
Zhang, Yue
Liu, Hui-Ying
Shen, Di
Che, Yi-Qun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) is a common subtype of non-Hodgkin’s lymphoma and is very likely to infiltrate the bone marrow.
Over 30% of patients are converted to relapsed/refractory DLBCL after first-line rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisone therapy, with a poor prognosis.
Our aim was to identify molecular markers that might be utilized to predict relapsed/refractory ABC-DLBCL patients.
Hence, we collected bone marrow aspirate smears from 202 patients with ABC-DLBCL and detected expression of bone marrow molecular marker proteins by immunocytochemistry.
Signal transducer and activator of transcription (Stat)3, nuclear factor (NF)-κB p65, Syk, Bruton’s tyrosine kinase (BTK), and Bcl2 proteins were strongly expressed in bone marrow aspirate smears of ABC-DLBCL patients.
The same smear could present positive expression of multiple proteins simultaneously.
Positive combinations of protein expression were associated with resistance.
The most significant finding was that the Stat3+NF-κB+ group developed resistance, which was significantly higher than that of the Stat3-NF-κB-group (80 vs.
14%).
There was a significant difference in two-year relapse-free survival between protein-positive and protein-negative combinations of Stat3-NF-κB (P = 0.005), Bcl2-Stat3 (P = 0.009), Bcl2-Pax5 (P = 0.003), and BTK-Syk (P < 0.001).
Thus, we detected key molecules in multiple signaling pathways in bone marrow aspirate smears.
At the same time, the results provide further clinical evidence of ABC-DLBCL drug-resistant molecules and provide a theoretical basis for rational second-line treatment after drug resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Di& Liu, Peng& Zhang, Yue& Liu, Hui-Ying& Shen, Di& Che, Yi-Qun. 2018. Bone Marrow Molecular Markers Associated with RelapsedRefractory Activated B-Cell-Like Diffuse Large B-Cell Lymphoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1124114
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Di…[et al.]. Bone Marrow Molecular Markers Associated with RelapsedRefractory Activated B-Cell-Like Diffuse Large B-Cell Lymphoma. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1124114
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Di& Liu, Peng& Zhang, Yue& Liu, Hui-Ying& Shen, Di& Che, Yi-Qun. Bone Marrow Molecular Markers Associated with RelapsedRefractory Activated B-Cell-Like Diffuse Large B-Cell Lymphoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1124114
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124114
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر