Function of Adipose-Derived Mesenchymal Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension through miR-191 via Regulation of BMPR2
المؤلفون المشاركون
Ni, Songshi
Zhang, Caixin
Wang, Pengbo
Mohammed, Anaz
Zhou, Zhewen
Zhang, Shuwen
Tang, Zhiyuan
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Pulmonary arterial hypertension (PAH) is a serious condition.
However, prevailing therapeutic strategies are not effective enough to treat PAH.
Therefore, finding an effective therapy is clearly warranted.
Adipose-derived mesenchymal stem cells (ASCs) and ASCs-derived exosomes (ASCs-Exos) exert protective effects in PAH, but the underlying mechanism remains unclear.
Using a coculture of ASCs and monocrotaline pyrrole (MCTP)-treated human pulmonary artery endothelial cells (HPAECs), we demonstrated that ASCs increased cell proliferation in MCTP-treated HPAECs.
Results showed that ASCs-Exos improved proliferation of both control HPAECs and MCTP-treated HPAECs.
In addition, by transfecting ASCs with antagomir we observed that low exosomal miR-191 expression inhibited HPAECs proliferation whereas the agomir improved.
Similar results were observed in vivo using a monocrotaline (MCT)-induced PAH rat model following ASCs transplantation.
And ASCs transplantation attenuated MCT-induced PAH albeit less than the antagomir treated group.
Finally, we found that miR-191 repressed the expression of bone morphogenetic protein receptor 2 (BMPR2) in HPAECs and PAH rats.
Thus, we conjectured that miR-191, in ASCs and ASCs-Exos, plays an important role in PAH via regulation of BMPR2.
These findings are expected to contribute to promising therapeutic strategies for treating PAH in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Caixin& Wang, Pengbo& Mohammed, Anaz& Zhou, Zhewen& Zhang, Shuwen& Ni, Songshi…[et al.]. 2019. Function of Adipose-Derived Mesenchymal Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension through miR-191 via Regulation of BMPR2. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1124121
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Caixin…[et al.]. Function of Adipose-Derived Mesenchymal Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension through miR-191 via Regulation of BMPR2. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1124121
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Caixin& Wang, Pengbo& Mohammed, Anaz& Zhou, Zhewen& Zhang, Shuwen& Ni, Songshi…[et al.]. Function of Adipose-Derived Mesenchymal Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension through miR-191 via Regulation of BMPR2. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1124121
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124121
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر