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Glycopatterns and Glycoproteins Changes in MCN and SCN: A Prospective Cohort Study
المؤلفون المشاركون
Wang, Ying
Sun, Yufa
Feng, Jia
Li, Zheng
Yu, Hanjie
Ding, Xiang
Yang, Fuquan
Linghu, Enqiang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Advances in imaging improve the detection of malignant pancreatic cystic including mucinous cystic neoplasm (MCN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic adenocarcinoma (MCA), but the distinction between benign and malignant lesions remains a problem.
In an effort to establish glycopatterns as potential biomarkers for differential diagnosis between MCN and SCN, we systematically investigated the alterations of glycopatterns in cystic fluids for both SCN and MCN.
Methods.
Among the 75 patients enrolled, 37 were diagnosed as MCN and 38 as SCN based on histology.
Lectin microarray analysis was performed on each sample, and the fluorescence intensity was used to obtain the fold-change.
Then, mixed cyst fluids of MCN group and SCN group were cross bonded with magnetic particles coupled by Lectin STL and WGA, respectively.
Hydrophilic interaction liquid chromatography (HILIC) enrichment was performed, liquid chromatography (LC)/mass spectrometry (MS) analysis and bioinformatical analysis was conducted to find the differential glycoproteins between MCNs and SCNs.
Results.
Through analysis of lectin microarray between MCNs and SCNs, stronger lectin signal patterns were assigned to Lectin WFA, DBA, STL, WGA, and BPL; and weaker signal patterns were assigned to Lectin PTL-I, Con A, ACA, and MAL-I.
The glycoproteins were enriched by STL or WGA-coupled magnetic particles.
Furthermore, the 10 identified correspondding genes were found to be significantly elevated in the mucinous cystadenoma: CLU, A2M, FGA, FGB, FGG, PLG, SERPINA1, SERPING1, C5, C8A, and C9.
Bioinformatics analysis revealed that the above genes may activate the KEGG pathway: immune complement system.
Conclusion.
This study shows changes in glycopatterns and glycoproteins are associated with MCNs and SCNs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ying& Sun, Yufa& Feng, Jia& Li, Zheng& Yu, Hanjie& Ding, Xiang…[et al.]. 2019. Glycopatterns and Glycoproteins Changes in MCN and SCN: A Prospective Cohort Study. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ying…[et al.]. Glycopatterns and Glycoproteins Changes in MCN and SCN: A Prospective Cohort Study. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1124156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ying& Sun, Yufa& Feng, Jia& Li, Zheng& Yu, Hanjie& Ding, Xiang…[et al.]. Glycopatterns and Glycoproteins Changes in MCN and SCN: A Prospective Cohort Study. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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